| Short Description : | Rabbit polyclonal NXN (100-280) antibody for use in WB, IF, ICC and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications: | WB/IF/ICC/ELISA |
| Host: | Rabbit |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Isotype: | IgG |
| Conjugation: | Unconjugated |
| Concentration: | Lot specific |
| Purification: | Affinity purification |
| Dilution Range: | WB:1:500-1:2000IF/ICC:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | NXN |
| Gene ID: | 64359 |
| Uniprot ID: | NXN_HUMAN |
| Immunogen Region: | 100-280 |
| Immunogen Sequence: | CRSLTRVLVESYRKIKEAGQ NFEIIFVSADRSEESFKQYF SEMPWLAVPYTDEARRSRLN RLYGIQGIPTLIMLDPQGEV ITRQGRVEVLNDEDCREFPW HPKPVLELSDSNAAQLNEGP CLVLFVDSEDDGESEAAKQL IQPIAEKIIAKYKAKEEEAP LLFFVAGEDDMTDSLRDYTN L |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 100-280 of human NXN (NP_001192248.1). |
| Function | Functions as a redox-dependent negative regulator of the Wnt signaling pathway, possibly by preventing ubiquitination of DVL3 by the BCR(KLHL12) complex. May also function as a transcriptional regulator act as a regulator of protein phosphatase 2A (PP2A). |
| Protein Name | Nucleoredoxin |
| Database Links | |
| Cellular Localisation | CytoplasmCytosolNucleus |
| Alternative Antibody Names | Anti-Nucleoredoxin antibodyAnti-NXN antibodyAnti-NRX antibody |
Information sourced from Uniprot.org
