| Function | Cleaves a beta-phosphate from the diphosphate groups in PP-InsP5 (diphosphoinositol pentakisphosphate) and PP2-InsP4 (bisdiphosphoinositol tetrakisphosphate), suggesting that it may play a role in signal transduction. InsP6 (inositol hexakisphosphate) is not a substrate. Acts as a negative regulator of the ERK1/2 pathway. Also able to catalyze the hydrolysis of dinucleoside oligophosphates, with diadenosine 5',5'''-P1,P6-hexaphosphate (Ap6A) and diadenosine 5',5'''- P1,P5-pentaphosphate (Ap5A) being the preferred substrates. The major reaction products are ADP and p4a from Ap6A and ADP and ATP from Ap5A. Also able to hydrolyze 5-phosphoribose 1-diphosphate. Acts as a decapping enzyme that modulates the stability of a subset of mRNAs implicated in cell motility. Hydrolyzes monomethylated capped RNA after both the alpha- and beta-phosphates generating m7GMP + ppRNA and m7GDP + pRNA. Can hydrolyze unmethylated capped RNAs. Divalent cations zinc, magnesium and manganese determine its substrate specificity. Exhibits diphosphoinositol polyphosphate phosphohydrolase in the presence of magnesium ions, diadenosine hexaphosphate hydrolase activity in the presence of manganese ions and endopolyphosphatase activity in the presence of zinc ions. Plays an important role in limiting DNA damage and maintaining cell survival upon oxidative stress via its endopolyphosphatase activity. |
| Protein Name | Diphosphoinositol Polyphosphate Phosphohydrolase 1Dipp-1Diadenosine Hexaphosphate HydrolaseAp6a HydrolaseEndopolyphosphataseNucleoside Diphosphate-Linked Moiety X Motif 3Nudix Motif 3M7gpppn-Mrna HydrolaseM7gpppx Diphosphatase |
| Database Links | Reactome: R-HSA-1855167 |
| Cellular Localisation | CytoplasmNucleus |
| Alternative Antibody Names | Anti-Diphosphoinositol Polyphosphate Phosphohydrolase 1 antibodyAnti-Dipp-1 antibodyAnti-Diadenosine Hexaphosphate Hydrolase antibodyAnti-Ap6a Hydrolase antibodyAnti-Endopolyphosphatase antibodyAnti-Nucleoside Diphosphate-Linked Moiety X Motif 3 antibodyAnti-Nudix Motif 3 antibodyAnti-M7gpppn-Mrna Hydrolase antibodyAnti-M7gpppx Diphosphatase antibodyAnti-NUDT3 antibodyAnti-DIPP antibodyAnti-DIPP1 antibody |
Information sourced from Uniprot.org
