| Tissue Specificity | Widely expressed with highest expression in thymus, testis, embryo and proliferating blood lymphocytes. |
| Post Translational Modifications | The N-terminus is blocked. |
| Function | Oxidized purine nucleoside triphosphate hydrolase which is a prominent sanitizer of the oxidized nucleotide pool. Catalyzes the hydrolysis of 2-oxo-dATP (2-hydroxy-dATP) into 2-oxo-dAMP. Has also a significant hydrolase activity toward 2-oxo-ATP, 8-oxo-dGTP and 8-oxo-dATP. Through the hydrolysis of oxidized purine nucleoside triphosphates, prevents their incorporation into DNA and the subsequent transversions A:T to C:G and G:C to T:A. Also catalyzes the hydrolysis of methylated purine nucleoside triphosphate preventing their integration into DNA. Through this antimutagenic activity protects cells from oxidative stress. |
| Protein Name | Oxidized Purine Nucleoside Triphosphate Hydrolase2-Hydroxy-Datp Diphosphatase7 -8-Dihydro-8-Oxoguanine Triphosphatase8-Oxo-DgtpaseMethylated Purine Nucleoside Triphosphate HydrolaseNucleoside Diphosphate-Linked Moiety X Motif 1Nudix Motif 1 |
| Database Links | Reactome: R-HSA-2393930 |
| Cellular Localisation | Isoform P18: CytoplasmCytosolMitochondrion MatrixNucleusMostly Present In CytosolA Minor Proportion Is MitochondrialA Very Small Amount Of The Protein Is Associated With NucleiIsoform P26: Mitochondrion Matrix |
| Alternative Antibody Names | Anti-Oxidized Purine Nucleoside Triphosphate Hydrolase antibodyAnti-2-Hydroxy-Datp Diphosphatase antibodyAnti-7 -8-Dihydro-8-Oxoguanine Triphosphatase antibodyAnti-8-Oxo-Dgtpase antibodyAnti-Methylated Purine Nucleoside Triphosphate Hydrolase antibodyAnti-Nucleoside Diphosphate-Linked Moiety X Motif 1 antibodyAnti-Nudix Motif 1 antibodyAnti-NUDT1 antibodyAnti-MTH1 antibody |
Information sourced from Uniprot.org
