| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-NUDT1 (1-179) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
NUDT1 |
| Gene ID: |
4521 |
| Uniprot ID: |
8ODP_HUMAN |
| Immunogen Region: |
1-179 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-179 of human MTH1 (NP_945192.1). |
| Immunogen Sequence: |
MSGISPQQMGEPEGSWSGKN PGTMGASRLYTLVLVLQPQR VLLGMKKRGFGAGRWNGFGG KVQEGETIEDGARRELQEES GLTVDALHKVGQIVFEFVGE PELMDVHVFCTDSIQGTPVE SDEMRPCWFQLDQIPFKDMW PDDSYWFPLLLQKKKFHGYF KFQGQDTILDYTLREVDTV |
| Tissue Specificity | Widely expressed with highest expression in thymus, testis, embryo and proliferating blood lymphocytes. |
| Post Translational Modifications | The N-terminus is blocked. |
| Function | Oxidized purine nucleoside triphosphate hydrolase which is a prominent sanitizer of the oxidized nucleotide pool. Catalyzes the hydrolysis of 2-oxo-dATP (2-hydroxy-dATP) into 2-oxo-dAMP. Has also a significant hydrolase activity toward 2-oxo-ATP, 8-oxo-dGTP and 8-oxo-dATP. Through the hydrolysis of oxidized purine nucleoside triphosphates, prevents their incorporation into DNA and the subsequent transversions A:T to C:G and G:C to T:A. Also catalyzes the hydrolysis of methylated purine nucleoside triphosphate preventing their integration into DNA. Through this antimutagenic activity protects cells from oxidative stress. |
| Protein Name | Oxidized Purine Nucleoside Triphosphate Hydrolase2-Hydroxy-Datp Diphosphatase7 -8-Dihydro-8-Oxoguanine Triphosphatase8-Oxo-DgtpaseMethylated Purine Nucleoside Triphosphate HydrolaseNucleoside Diphosphate-Linked Moiety X Motif 1Nudix Motif 1 |
| Database Links | Reactome: R-HSA-2393930 |
| Cellular Localisation | Isoform P18: CytoplasmCytosolMitochondrion MatrixNucleusMostly Present In CytosolA Minor Proportion Is MitochondrialA Very Small Amount Of The Protein Is Associated With NucleiIsoform P26: Mitochondrion Matrix |
| Alternative Antibody Names | Anti-Oxidized Purine Nucleoside Triphosphate Hydrolase antibodyAnti-2-Hydroxy-Datp Diphosphatase antibodyAnti-7 -8-Dihydro-8-Oxoguanine Triphosphatase antibodyAnti-8-Oxo-Dgtpase antibodyAnti-Methylated Purine Nucleoside Triphosphate Hydrolase antibodyAnti-Nucleoside Diphosphate-Linked Moiety X Motif 1 antibodyAnti-Nudix Motif 1 antibodyAnti-NUDT1 antibodyAnti-MTH1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
