Anti-NTHL1 antibody (190-290) {FITC} (STJ501983)

SKU:
STJ501983-100

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Host: Rabbit
Applications: ELISA/WB
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-NTHL1 (190-290) is suitable for use in ELISA and Western Blot research applications.
Clonality: Polyclonal
Conjugation: FITC
Isotype: IgG
Purification: Affinity Purified
Concentration: 0.64-0.72 µg/µl
Dilution Range: WB: 1:500
DB: 1:10, 000
ELISA: 1:10, 000
Storage Instruction: Store at-20°C for long term storage. Avoid freeze-thaw cycles.
Gene Symbol: NTHL1
Gene ID: 4913
Uniprot ID: NTH_HUMAN
Immunogen Region: 190-290
Immunogen: C-epitope synthetic peptide taken within amino acid region 190-290 on human NTHL1 protein.
Tissue Specificity Widely expressed with highest levels in heart and lowest levels in lung and liver.
Post Translational Modifications Ubiquitinated by TRIM26.leading to proteasomal degradation.
Function Bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic (AP) lyase function that catalyzes the first step in base excision repair (BER), the primary repair pathway for the repair of oxidative DNA damage. The DNA N-glycosylase activity releases the damaged DNA base from DNA by cleaving the N-glycosidic bond, leaving an AP site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination. Primarily recognizes and repairs oxidative base damage of pyrimidines. Has also 8-oxo-7,8-dihydroguanine (8-oxoG) DNA glycosylase activity. Acts preferentially on DNA damage opposite guanine residues in DNA. Is able to process lesions in nucleosomes without requiring or inducing nucleosome disruption.
Protein Name Endonuclease Iii-Like Protein 1
Hnth1
Bifunctional Dna N-Glycosylase/Dna-(Apurinic Or Apyrimidinic Site Lyase
Dna Glycosylase/Ap Lyase
Database Links Reactome: R-HSA-110328
Reactome: R-HSA-110329
Reactome: R-HSA-110357
Reactome: R-HSA-9630221
Reactome: R-HSA-9630222
Cellular Localisation Nucleus
Mitochondrion
Alternative Antibody Names Anti-Endonuclease Iii-Like Protein 1 antibody
Anti-Hnth1 antibody
Anti-Bifunctional Dna N-Glycosylase/Dna-(Apurinic Or Apyrimidinic Site Lyase antibody
Anti-Dna Glycosylase/Ap Lyase antibody
Anti-NTHL1 antibody
Anti-NTH1 antibody
Anti-OCTS3 antibody

Information sourced from Uniprot.org

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