| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-NRIP1 (939-1158) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
NRIP1 |
| Gene ID: |
8204 |
| Uniprot ID: |
NRIP1_HUMAN |
| Immunogen Region: |
939-1158 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 939-1158 of human NRIP1 (NP_003480.2). |
| Immunogen Sequence: |
LLLSENCVRDLSPHRSNSVA DSKKKGHKNNVTNSKPEFSI SSLNGLMYSSTQPSSCMDNR TFSYPGVVKTPVSPTFPEHL GCAGSRPESGLLNGCSMPSE KGPIKWVITDAEKNEYEKDS PRLTKTNPILYYMLQKGGNS VTSRETQDKDIWREASSAES VSQVTAKEELLPTAETKASF FNLRSPYNSHMGNNASRPHS ANGEVYGLLGSVLTIKKESE |
| Post Translational Modifications | Acetylation regulates its nuclear translocation and corepressive activity. Acetylation abolishes interaction with CTBP1. Phosphorylation enhances interaction with YWHAH. |
| Function | Modulates transcriptional activation by steroid receptors such as NR3C1, NR3C2 and ESR1. Also modulates transcriptional repression by nuclear hormone receptors. Positive regulator of the circadian clock gene expression: stimulates transcription of BMAL1, CLOCK and CRY1 by acting as a coactivator for RORA and RORC. Involved in the regulation of ovarian function. Plays a role in renal development. |
| Protein Name | Nuclear Receptor-Interacting Protein 1Nuclear Factor Rip140Receptor-Interacting Protein 140 |
| Database Links | Reactome: R-HSA-3899300Reactome: R-HSA-400253Reactome: R-HSA-9018519Reactome: R-HSA-9029558Reactome: R-HSA-9632974Reactome: R-HSA-9707616 |
| Cellular Localisation | NucleusLocalized To Discrete Foci And Redistributes To Larger Nuclear Domains Upon Binding To Ligand-Bound Nr3c1 |
| Alternative Antibody Names | Anti-Nuclear Receptor-Interacting Protein 1 antibodyAnti-Nuclear Factor Rip140 antibodyAnti-Receptor-Interacting Protein 140 antibodyAnti-NRIP1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
