| Applications: | WB/ELISA/ChIP |
| Host: | Rabbit |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Isotype: | IgG |
| Conjugation: | Unconjugated |
| Concentration: | Lot specific |
| Purification: | Affinity purification |
| Dilution Range: | WB:1:500-1:1000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements.ChIP:5 Mu g antibody for 10 Mu g-15 Mu g of Chromatin |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | NRF1 |
| Gene ID: | 4899 |
| Uniprot ID: | NRF1_HUMAN |
| Immunogen Region: | 240-449 |
| Immunogen Sequence: | WANVRSDVRTEEQKQRVSWT QALRTIVKNCYKQHGREDLL YAFEDQQTQTQATATHSIAH LVPSQTVVQTFSNPDGTVSL IQVGTGATVATLADASELPT TVTVAQVNYSAVADGEVEQN WATLQGGEMTIQTTQASEAT QAVASLAEAAVAASQEMQQG ATVTMALNSEAAAHAVATLA EATLQGGGQIVLSGETAAAV GALTGVQDAN |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 240-449 of human NRF1 (NP_001035199.1). |
| Tissue Specificity | Ubiquitously expressed with strongest expression in skeletal muscle. |
| Post Translational Modifications | Phosphorylation enhances DNA binding. |
| Function | Transcription factor that activates the expression of the EIF2S1 (EIF2-alpha) gene. Links the transcriptional modulation of key metabolic genes to cellular growth and development. Implicated in the control of nuclear genes required for respiration, heme biosynthesis, and mitochondrial DNA transcription and replication. |
| Protein Name | Nuclear Respiratory Factor 1Nrf-1Alpha Palindromic-Binding ProteinAlpha-Pal |
| Database Links | Reactome: R-HSA-1989781Reactome: R-HSA-2151201Reactome: R-HSA-9841251 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Nuclear Respiratory Factor 1 antibodyAnti-Nrf-1 antibodyAnti-Alpha Palindromic-Binding Protein antibodyAnti-Alpha-Pal antibodyAnti-NRF1 antibody |
Information sourced from Uniprot.org
