| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-NR0B2 (40-124) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.05% Proclin300, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:1000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
NR0B2 |
| Gene ID: |
8431 |
| Uniprot ID: |
NR0B2_HUMAN |
| Immunogen Region: |
40-124 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 40-124 of human SHP/NR0B2 (NP_068804.1). |
| Immunogen Sequence: |
LCRQHRPVQLCAPHRTCREA LDVLAKTVAFLRNLPSFWQL PPQDQRRLLQGCWGPLFLLG LAQDAVTFEVAEAPVPSILK KILLE |
| Tissue Specificity | Liver. Low levels of expression were detected in heart and pancreas. |
| Post Translational Modifications | Arginine methylation by PRMT5 enhances repression activity of metabolic genes in liver in response to bile acid signaling, by increasing interaction with cofactors. |
| Function | Transcriptional regulator that acts as a negative regulator of receptor-dependent signaling pathways. Specifically inhibits transactivation of the nuclear receptor with which it interacts. Inhibits transcriptional activity of NEUROD1 on E-box-containing promoter by interfering with the coactivation function of the p300/CBP-mediated transcription complex for NEUROD1. Essential component of the liver circadian clock which via its interaction with NR1D1 and RORG regulates NPAS2-mediated hepatic lipid metabolism. Regulates the circadian expression of cytochrome P450 (CYP) enzymes. Represses: NR5A2 and HNF4A to down-regulate CYP2C38, NFLI3 to up-regulate CYP2A5, BHLHE41/HNF1A axis to up-regulate CYP1A2, CYP2E1 and CYP3A11, and NR1D1 to up-regulate CYP2B10, CYP4A10 and CYP4A14. |
| Protein Name | Nuclear Receptor Subfamily 0 Group B Member 2Orphan Nuclear Receptor ShpSmall Heterodimer Partner |
| Database Links | Reactome: R-HSA-383280 |
| Cellular Localisation | NucleusCytoplasmColocalizes With Neurod1 In The Nucleus |
| Alternative Antibody Names | Anti-Nuclear Receptor Subfamily 0 Group B Member 2 antibodyAnti-Orphan Nuclear Receptor Shp antibodyAnti-Small Heterodimer Partner antibodyAnti-NR0B2 antibodyAnti-SHP antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
