| Function | As a component of the GATOR1 complex functions as an inhibitor of the amino acid-sensing branch of the mTORC1 pathway. In response to amino acid depletion, the GATOR1 complex has GTPase activating protein (GAP) activity and strongly increases GTP hydrolysis by RagA/RRAGA (or RagB/RRAGB) within heterodimeric Rag complexes, thereby turning them into their inactive GDP-bound form, releasing mTORC1 from lysosomal surface and inhibiting mTORC1 signaling. In the presence of abundant amino acids, the GATOR1 complex is negatively regulated by GATOR2, the other GATOR subcomplex, in this amino acid-sensing branch of the TORC1 pathway. |
| Protein Name | Gator1 Complex Protein Nprl3-14 Gene ProteinAlpha-Globin Regulatory Element-Containing Gene ProteinNitrogen Permease Regulator 3-Like ProteinProtein Cgthba |
| Database Links | Reactome: R-HSA-9639288 |
| Cellular Localisation | Lysosome MembraneLocalization To Lysosomes Is Mediated By The Kicstor Complex And Is Amino Acid-Independent |
| Alternative Antibody Names | Anti-Gator1 Complex Protein Nprl3 antibodyAnti--14 Gene Protein antibodyAnti-Alpha-Globin Regulatory Element-Containing Gene Protein antibodyAnti-Nitrogen Permease Regulator 3-Like Protein antibodyAnti-Protein Cgthba antibodyAnti-NPRL3 antibodyAnti-C16orf35 antibodyAnti-CGTHBA antibodyAnti-MARE antibody |
Information sourced from Uniprot.org
