| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:1000-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | NPR3 |
| Gene ID: | 4883 |
| Uniprot ID: | ANPRC_HUMAN |
| Immunogen Region: | 272-541 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 272-541 of human NPR3 (NP_001191304.1). |
| Immunogen Sequence: | LVAHRHGMTSGDYAFFNIEL FNSSSYGDGSWKRGDKHDFE AKQAYSSLQTVTLLRTVKPE FEKFSMEVKSSVEKQGLNME DYVNMFVEGFHDAILLYVLA LHEVLRAGYSKKDGGKIIQQ TWNRTFEGIAGQVSIDANGD RYGDFSVIAMTDVEAGTQEV IGDYFGKEGRFEMRPNVKYP WGPLKLRIDENRIVEHTNSS PCKSSGGLEESAVTGIVVGA LLGAGLLMAFYFFRKKYRI |
| Function | Receptor for the natriuretic peptide hormones, binding with similar affinities atrial natriuretic peptide NPPA/ANP, brain natriuretic peptide NPPB/BNP, and C-type natriuretic peptide NPPC/CNP. May function as a clearance receptor for NPPA, NPPB and NPPC, regulating their local concentrations and effects. Acts as a regulator of osteoblast differentiation and bone growth by binding to its ligand osteocrin, thereby preventing binding between NPR3/NPR-C and natriuretic peptides, leading to increase cGMP production. |
| Protein Name | Atrial Natriuretic Peptide Receptor 3Atrial Natriuretic Peptide Clearance ReceptorAtrial Natriuretic Peptide Receptor Type CAnp-CAnpr-CNpr-C |
| Database Links | |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane Protein |
| Alternative Antibody Names | Anti-Atrial Natriuretic Peptide Receptor 3 antibodyAnti-Atrial Natriuretic Peptide Clearance Receptor antibodyAnti-Atrial Natriuretic Peptide Receptor Type C antibodyAnti-Anp-C antibodyAnti-Anpr-C antibodyAnti-Npr-C antibodyAnti-NPR3 antibodyAnti-ANPRC antibodyAnti-C5orf23 antibodyAnti-NPRC antibody |
Information sourced from Uniprot.org
