| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.05% Proclin300, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:1000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | NPHS2 |
| Gene ID: | 7827 |
| Uniprot ID: | PODO_HUMAN |
| Immunogen Region: | 300-388 |
| Specificity: | A synthetic peptide corresponding to a sequence within amino acids 300-388 of human NPHS2 (NP_055440.1). |
| Immunogen Sequence: | AASESLRMAAEILSGTPAAV QLRYLHTLQSLSTEKPSTVV LPLPFDLLNCLSSPSNRTQG SLPFPSPSKPVEPLNPKKKD SPML |
| Tissue Specificity | Almost exclusively expressed in the podocytes of fetal and mature kidney glomeruli. |
| Post Translational Modifications | Isoform 2: Glycosylated. |
| Function | Plays a role in the regulation of glomerular permeability, acting probably as a linker between the plasma membrane and the cytoskeleton. |
| Protein Name | Podocin |
| Database Links | Reactome: R-HSA-373753 |
| Cellular Localisation | Isoform 1: Cell MembranePeripheral Membrane ProteinIsoform 2: Endoplasmic Reticulum |
| Alternative Antibody Names | Anti-Podocin antibodyAnti-NPHS2 antibody |
Information sourced from Uniprot.org