| Short Description : | Rabbit polyclonal anti-Nephrocystin-3 (1092-1142 aa) for use in WB in Human and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications: | WB |
| Host: | Rabbit |
| Reactivity: | Human/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Isotype: | IgG |
| Conjugation: | Unconjugated |
| Concentration: | 1 mg/mL |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range: | WB 1:500-2000 |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | NPHP3 |
| Gene ID: | 27031 |
| Uniprot ID: | NPHP3_HUMAN |
| Immunogen: | Synthesized peptide derived from the human NPHP3 at the amino acid range 1092-1142 |
| Immunogen Region: | 1092-1142 aa |
| Specificity: | This antibody detects endogenous levels of NPHP3 at Human/Mouse |
| Function | Required for normal ciliary development and function. Inhibits disheveled-1-induced canonical Wnt-signaling activity and may also play a role in the control of non-canonical Wnt signaling which regulates planar cell polarity. Probably acts as a molecular switch between different Wnt signaling pathways. Required for proper convergent extension cell movements. |
| Protein Name | Nephrocystin-3 |
| Database Links | Reactome: R-HSA-5624138 |
| Cellular Localisation | Cell ProjectionCiliumLocalization To Cilium Is Mediated Via Interaction With Unc119 And Unc119bWhich Bind To The Myristoyl Moiety Of The N-Terminus |
| Alternative Antibody Names | Anti-Nephrocystin-3 antibodyAnti-NPHP3 antibodyAnti-KIAA2000 antibody |
Information sourced from Uniprot.org
