| Post Translational Modifications | Synthesized in the endoplasmic reticulum as an inactive form which is proteolytically cleaved by a furin-like convertase in the trans-Golgi network before it reaches the plasma membrane to yield an active, ligand-accessible form. Cleavage results in a C-terminal fragment N(TM) and a N-terminal fragment N(EC). Following ligand binding, it is cleaved by TNF-alpha converting enzyme (TACE) to yield a membrane-associated intermediate fragment called notch extracellular truncation (NEXT). This fragment is then cleaved by presenilin dependent gamma-secretase to release a notch-derived peptide containing the intracellular domain (NICD) from the membrane. Phosphorylated. Hydroxylated by HIF1AN. |
| Function | Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. |
| Protein Name | Neurogenic Locus Notch Homolog Protein 3Notch 3 Cleaved Into - Notch 3 Extracellular Truncation - Notch 3 Intracellular Domain |
| Database Links | Reactome: R-HSA-1912399Reactome: R-HSA-1912408Reactome: R-HSA-1912420Reactome: R-HSA-350054Reactome: R-HSA-5083630Reactome: R-HSA-9013507Reactome: R-HSA-9013508Reactome: R-HSA-9017802 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane ProteinNotch 3 Intracellular Domain: NucleusFollowing Proteolytical Processing Nicd Is Translocated To The Nucleus |
| Alternative Nanobody Names | Anti-Neurogenic Locus Notch Homolog Protein 3 nanobodyAnti-Notch 3 Cleaved Into - Notch 3 Extracellular Truncation - Notch 3 Intracellular Domain nanobodyAnti-NOTCH3 nanobody |
Information sourced from Uniprot.org
![Anti-NOTCH3 nanobody [SAA1288] (STJN000313)](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/124x110/products/200926/413108/STJN000313-SDS-PAGE-1__91078.1749232608.jpg?c=1 "Anti-NOTCH3 nanobody [SAA1288] (STJN000313)")
![Anti-NOTCH3 nanobody [SAA1288] (STJN000313)](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/1280x1280/products/200926/413108/STJN000313-SDS-PAGE-1__91078.1749232608.jpg?c=1 "Anti-NOTCH3 nanobody [SAA1288] (STJN000313)")
