| Function | With DHDDS, forms the dehydrodolichyl diphosphate synthase (DDS) complex, an essential component of the dolichol monophosphate (Dol-P) biosynthetic machinery. Both subunits contribute to enzymatic activity, i.e. condensation of multiple copies of isopentenyl pyrophosphate (IPP) to farnesyl pyrophosphate (FPP) to produce dehydrodolichyl diphosphate (Dedol-PP), a precursor of dolichol phosphate which is utilized as a sugar carrier in protein glycosylation in the endoplasmic reticulum (ER). Synthesizes long-chain polyprenols, mostly of C95 and C100 chain length. Regulates the glycosylation and stability of nascent NPC2, thereby promoting trafficking of LDL-derived cholesterol. Acts as a specific receptor for the N-terminus of Nogo-B, a neural and cardiovascular regulator. |
| Protein Name | Dehydrodolichyl Diphosphate Synthase Complex Subunit Nus1Cis-Prenyltransferase Subunit NgbrNogo-B ReceptorNgbrNuclear Undecaprenyl Pyrophosphate Synthase 1 Homolog |
| Database Links | Reactome: R-HSA-446199Reactome: R-HSA-4755609 |
| Cellular Localisation | Endoplasmic Reticulum MembraneMulti-Pass Membrane ProteinColocalizes With Nogo-B During Vegf And Wound Healing Angiogenesis |
| Alternative Antibody Names | Anti-Dehydrodolichyl Diphosphate Synthase Complex Subunit Nus1 antibodyAnti-Cis-Prenyltransferase Subunit Ngbr antibodyAnti-Nogo-B Receptor antibodyAnti-Ngbr antibodyAnti-Nuclear Undecaprenyl Pyrophosphate Synthase 1 Homolog antibodyAnti-NUS1 antibodyAnti-C6orf68 antibodyAnti-NGBR antibody |
Information sourced from Uniprot.org
