Anti-Nogo B Receptor antibody [R01-3K8] (STJA0034648)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenA synthetic peptide of human Nogo B receptor
General Information
| Short Description | Rabbit monoclonal anti-Nogo B Receptor for use in WB in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | R01-3K8 |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 0.3 mg/mL |
| Purification | Affinity Purified |
| Dilution Range | WB 1:500-1:1000 |
| Formulation | 50mM Tris-Glycine (pH 7.4) , 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA |
| Storage Instruction | Store at 4°C short term. Aliquot and store at-20°C long term. Avoid freeze/thaw cycles. |
Target Information
| Gene Symbol | NUS1 |
| Gene ID | 116150 |
| Uniprot ID | NGBR_HUMAN |
| Immunogen | A synthetic peptide of human Nogo B receptor |
Additional Info
| Function | With DHDDS, forms the dehydrodolichyl diphosphate synthase (DDS) complex, an essential component of the dolichol monophosphate (Dol-P) biosynthetic machinery. Both subunits contribute to enzymatic activity, i.e. condensation of multiple copies of isopentenyl pyrophosphate (IPP) to farnesyl pyrophosphate (FPP) to produce dehydrodolichyl diphosphate (Dedol-PP), a precursor of dolichol phosphate which is utilized as a sugar carrier in protein glycosylation in the endoplasmic reticulum (ER). Synthesizes long-chain polyprenols, mostly of C95 and C100 chain length. Regulates the glycosylation and stability of nascent NPC2, thereby promoting trafficking of LDL-derived cholesterol. Acts as a specific receptor for the N-terminus of Nogo-B, a neural and cardiovascular regulator. |
| Protein Name | Dehydrodolichyl Diphosphate Synthase Complex Subunit Nus1Cis-Prenyltransferase Subunit NgbrNogo-B ReceptorNgbrNuclear Undecaprenyl Pyrophosphate Synthase 1 Homolog |
| Database Links | Reactome: R-HSA-446199Reactome: R-HSA-4755609 |
| Cellular Localisation | Endoplasmic Reticulum MembraneMulti-Pass Membrane ProteinColocalizes With Nogo-B During Vegf And Wound Healing Angiogenesis |
| Alternative Antibody Names | Anti-Dehydrodolichyl Diphosphate Synthase Complex Subunit Nus1 antibodyAnti-Cis-Prenyltransferase Subunit Ngbr antibodyAnti-Nogo-B Receptor antibodyAnti-Ngbr antibodyAnti-Nuclear Undecaprenyl Pyrophosphate Synthase 1 Homolog antibodyAnti-NUS1 antibodyAnti-C6orf68 antibodyAnti-NGBR antibody |
Information sourced from Uniprot.org