| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.05% Proclin300, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:100-1:500ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | NKX3-2 |
| Gene ID: | 579 |
| Uniprot ID: | NKX32_HUMAN |
| Immunogen Region: | 1-180 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-180 of human NKX3-2 (NP_001180.1). |
| Immunogen Sequence: | MAVRGANTLTSFSIQAILNK KEERGGLAAPEGRPAPGGTA ASVAAAPAVCCWRLFGERDA GALGGAEDSLLASPAGTRTA AGRTAESPEGWDSDSALSEE NESRRRCADARGASGAGLAG GSLSLGQPVCELAASKDLEE EAAGRSDSEMSASVSGDRSP RTEDDGVGPRGAHVSALCSG |
| Tissue Specificity | Expressed at highest levels in cartilage, bone (osteosarcoma) and gut (small intestine and colon), whereas moderate expression is seen in trachea and brain. Expressed in visceral mesoderm and embryonic skeleton. |
| Function | Transcriptional repressor that acts as a negative regulator of chondrocyte maturation. PLays a role in distal stomach development.required for proper antral-pyloric morphogenesis and development of antral-type epithelium. In concert with GSC, defines the structural components of the middle ear.required for tympanic ring and gonium development and in the regulation of the width of the malleus. |
| Protein Name | Homeobox Protein Nkx-3.2Bagpipe Homeobox Protein Homolog 1Homeobox Protein Nk-3 Homolog B |
| Database Links | Reactome: R-HSA-8939902 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Homeobox Protein Nkx-3.2 antibodyAnti-Bagpipe Homeobox Protein Homolog 1 antibodyAnti-Homeobox Protein Nk-3 Homolog B antibodyAnti-NKX3-2 antibodyAnti-BAPX1 antibodyAnti-NKX3B antibody |
Information sourced from Uniprot.org