| Tissue Specificity | Detected in heart, brain, placenta, liver, skeletal muscle, kidney and pancreas. |
| Function | Catalyzes the hydrolysis of the amide bond in N-(4-oxoglutarate)-L-cysteinylglycine (deaminated glutathione), a metabolite repair reaction to dispose of the harmful deaminated glutathione. Plays a role in cell growth and apoptosis: loss of expression promotes cell growth, resistance to DNA damage stress and increased incidence to NMBA-induced tumors. Has tumor suppressor properties that enhances the apoptotic responsiveness in cancer cells.this effect is additive to the tumor suppressor activity of FHIT. It is also a negative regulator of primary T-cells. |
| Protein Name | Deaminated Glutathione AmidaseDgsh AmidaseNitrilase Homolog 1 |
| Database Links | |
| Cellular Localisation | Isoform 2: MitochondrionIsoform 1: Cytoplasm |
| Alternative Antibody Names | Anti-Deaminated Glutathione Amidase antibodyAnti-Dgsh Amidase antibodyAnti-Nitrilase Homolog 1 antibodyAnti-NIT1 antibody |
Information sourced from Uniprot.org
