Anti-NIPBL antibody (560-640 aa) (STJ191086)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from the human protein at the amino acid range 560-640
General Information
| Short Description | Rabbit polyclonal anti-Nipped-B-like protein (560-640 aa) for use in IHC and IF in Human and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | IHC/IF |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | IHC-P 1:50-300IF 1:50-200 |
| Formulation | Liquid in PBS containing 50% Glycerol and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | NIPBL |
| Gene ID | 25836 |
| Uniprot ID | NIPBL_HUMAN |
| Immunogen | Synthesized peptide derived from the human protein at the amino acid range 560-640 |
| Immunogen Region | 560-640 aa |
| Specificity | NIPBL Polyclonal Antibody detects endogenous levels of protein. |
Additional Info
| Function | Plays an important role in the loading of the cohesin complex on to DNA. Forms a heterodimeric complex (also known as cohesin loading complex) with MAU2/SCC4 which mediates the loading of the cohesin complex onto chromatin. Plays a role in cohesin loading at sites of DNA damage. Its recruitment to double-strand breaks (DSBs) sites occurs in a CBX3-, RNF8- and RNF168-dependent manner whereas its recruitment to UV irradiation-induced DNA damage sites occurs in a ATM-, ATR-, RNF8- and RNF168-dependent manner. Along with ZNF609, promotes cortical neuron migration during brain development by regulating the transcription of crucial genes in this process. Preferentially binds promoters containing paused RNA polymerase II. Up-regulates the expression of SEMA3A, NRP1, PLXND1 and GABBR2 genes, among others. |
| Protein Name | Nipped-B-Like ProteinDelanginScc2 Homolog |
| Database Links | Reactome: R-HSA-2470946 |
| Cellular Localisation | NucleusChromosome |
| Alternative Antibody Names | Anti-Nipped-B-Like Protein antibodyAnti-Delangin antibodyAnti-Scc2 Homolog antibodyAnti-NIPBL antibodyAnti-IDN3 antibodyAnti-SCC2 antibody |
Information sourced from Uniprot.org