• Immunohistochemistry analysis of I Kappa B-Zeta in paraffin-embedded mouse spleen tissue using I Kappa B-Zeta Rabbit polyclonal antibody (STJ11105623) at a dilution of 1:800 (40x lens). High pressure antigen retrieval was performed with 0. 01 M citrate buffer (pH 6. 0) prior to immunohistochemistry staining.
  • Immunohistochemistry analysis of I Kappa B-Zeta in paraffin-embedded mouse heart tissue using I Kappa B-Zeta Rabbit polyclonal antibody (STJ11105623) at a dilution of 1:800 (40x lens). High pressure antigen retrieval was performed with 0. 01 M citrate buffer (pH 6. 0) prior to immunohistochemistry staining.

Anti-NFKBIZ antibody (1-100) (STJ11105623)

SKU:
STJ11105623

£112.50 - £524.50
Current Stock:
Host: Rabbit
Applications: IHC-P/ELISA
Reactivity: Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.05% Proclin300, 50% Glycerol, pH 7.3.
Purification: Affinity purification
Concentration: Lot specific
Dilution Range: IHC-P:1:500-1:1000
ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements.
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: NFKBIZ
Gene ID: 64332
Uniprot ID: IKBZ_HUMAN
Immunogen Region: 1-100
Specificity: A synthetic peptide corresponding to a sequence within amino acids 1-100 of human I Kappa B-Zeta (NP_113607.1).
Immunogen Sequence: MIVDKLLDDSRGGEGLRDAA GGCGLMTSPLNLSYFYGASP PAAAPGACDASCSVLGPSAP GSPGSDSSDFSSASSVSSCG AVESRSRGGARAERQPVEPH
Tissue Specificity Expressed at high levels in peripheral blood leukocytes and lung, at moderate levels in liver, placenta, and at low levels in spleen, kidney, skeletal muscle and heart.
Function Involved in regulation of NF-kappa-B transcription factor complexes. Inhibits NF-kappa-B activity without affecting its nuclear translocation upon stimulation. Inhibits DNA-binding of RELA and NFKB1/p50, and of the NF-kappa-B p65-p50 heterodimer and the NF-kappa-B p50-p50 homodimer. Seems also to activate NF-kappa-B-mediated transcription. In vitro, upon association with NFKB1/p50 has transcriptional activation activity and, together with NFKB1/p50 and RELA, is recruited to LCN2 promoters. Promotes transcription of LCN2 and DEFB4. Is recruited to IL-6 promoters and activates IL-6 but decreases TNF-alpha production in response to LPS. Seems to be involved in the induction of inflammatory genes activated through TLR/IL-1 receptor signaling. Involved in the induction of T helper 17 cells (Th17) differentiation upon recognition of antigen by T cell antigen receptor (TCR).
Protein Name Nf-Kappa-B Inhibitor Zeta
I-Kappa-B-Zeta
Ikb-Zeta
Ikappabzeta
Il-1 Inducible Nuclear Ankyrin-Repeat Protein
Inap
Molecule Possessing Ankyrin Repeats Induced By Lipopolysaccharide
Mail
Cellular Localisation Nucleus
Aggregated In Dot-Like Structures
Colocalizes With Ncor2
Alternative Antibody Names Anti-Nf-Kappa-B Inhibitor Zeta antibody
Anti-I-Kappa-B-Zeta antibody
Anti-Ikb-Zeta antibody
Anti-Ikappabzeta antibody
Anti-Il-1 Inducible Nuclear Ankyrin-Repeat Protein antibody
Anti-Inap antibody
Anti-Molecule Possessing Ankyrin Repeats Induced By Lipopolysaccharide antibody
Anti-Mail antibody
Anti-NFKBIZ antibody
Anti-IKBZ antibody
Anti-INAP antibody
Anti-MAIL antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance