| Host: |
Goat |
| Applications: |
Pep-ELISA/WB |
| Reactivity: |
Human/Dog/Cow |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Goat polyclonal antibody anti-NFATC3/NFAT4 (Internal) is suitable for use in ELISA and Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Purification: |
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Concentration: |
0.5 mg/mL |
| Dilution Range: |
WB-0.03-0.1µg/mlELISA-antibody detection limit dilution 1:16000. |
| Storage Instruction: |
Store at-20°C on receipt and minimise freeze-thaw cycles. |
| Gene Symbol: |
NFATC3 |
| Gene ID: |
4775 |
| Uniprot ID: |
NFAC3_HUMAN |
| Immunogen Region: |
Internal |
| Accession Number: |
NP_775188.1; NP_004546.1; NP_775186.1; NP_775187.1 |
| Specificity: |
This antibody is expected to recognize all four reported isoforms (NP_775188.1; NP_004546.1; NP_775186.1; NP_775187.1). |
| Immunogen Sequence: |
HQELDAHEDDLQIN |
| Post Translational Modifications | Phosphorylated by NFATC-kinase.dephosphorylated by calcineurin. |
| Function | Acts as a regulator of transcriptional activation. Plays a role in the inducible expression of cytokine genes in T-cells, especially in the induction of the IL-2. Along with NFATC4, involved in embryonic heart development. |
| Protein Name | Nuclear Factor Of Activated T-Cells - Cytoplasmic 3Nf-Atc3Nfatc3NfatxT-Cell Transcription Factor Nfat4Nf-At4Nf-At4c |
| Database Links | Reactome: R-HSA-2025928Reactome: R-HSA-2871809Reactome: R-HSA-5607763 |
| Cellular Localisation | CytoplasmNucleusCytoplasmic For The Phosphorylated Form And Nuclear After Activation That Is Controlled By Calcineurin-Mediated DephosphorylationRapid Nuclear Exit Of Nfatc Is Thought To Be One Mechanism By Which Cells Distinguish Between Sustained And Transient Calcium SignalsThe Subcellular Localization Of Nfatc Plays A Key Role In The Regulation Of Gene Transcription |
| Alternative Antibody Names | Anti-Nuclear Factor Of Activated T-Cells - Cytoplasmic 3 antibodyAnti-Nf-Atc3 antibodyAnti-Nfatc3 antibodyAnti-Nfatx antibodyAnti-T-Cell Transcription Factor Nfat4 antibodyAnti-Nf-At4 antibodyAnti-Nf-At4c antibodyAnti-NFATC3 antibodyAnti-NFAT4 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
