| Host: | Rabbit |
| Applications: | WB/IF/ICC/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000IF/ICC:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | NEXN |
| Gene ID: | 91624 |
| Uniprot ID: | NEXN_HUMAN |
| Immunogen Region: | 516-675 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 516-675 of human NEXN (NP_653174.3). |
| Immunogen Sequence: | RFEQMAKAREEEEQRRIEEQ KLLRMQFEQREIDAALQKKR EEEEEEEGSIMNGSTAEDEE QTRSGAPWFKKPLKNTSVVD SEPVRFTVKVTGEPKPEITW WFEGEILQDGEDYQYIERGE TYCLYLPETFPEDGGEYMCK AVNNKGSAASTCILTIESKN |
| Tissue Specificity | Abundantly expressed in heart and skeletal muscle, and at lower levels in placenta, lung, liver and pancreas. Also expressed in HeLaS3 and MOLT-4 cell lines. |
| Function | Involved in regulating cell migration through association with the actin cytoskeleton. Has an essential role in the maintenance of Z line and sarcomere integrity. |
| Protein Name | NexilinF-Actin-Binding ProteinNelin |
| Cellular Localisation | CytoplasmCytoskeletonCell JunctionAdherens JunctionMyofibrilSarcomereZ LineLocalizes To The Cell-Matrix AjNot Found At The Cell-Cell Aj |
| Alternative Antibody Names | Anti-Nexilin antibodyAnti-F-Actin-Binding Protein antibodyAnti-Nelin antibodyAnti-NEXN antibody |
Information sourced from Uniprot.org