| Host: | Goat |
| Applications: | Pep-ELISA/WB |
| Reactivity: | Human/Mouse/Rat/Dog |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Goat polyclonal antibody anti-Neuregulin 3 (C-Term) is suitable for use in ELISA and Western Blot research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Purification: | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Concentration: | 0.5 mg/mL |
| Dilution Range: | Peptide ELISA: antibody detection limit dilution 1:64000.WB: Approx 75kDa band observed in Human Brain (Cerebellum) lysates and in Mouse and Rat Brain lysates (calculated MW of 75.0kDa according to NP_001010848.2). Recommended concentration: 0.1 |
| Storage Instruction: | Store at-20°C on receipt and minimise freeze-thaw cycles. |
| Gene Symbol: | NRG3 |
| Gene ID: | 10718 |
| Uniprot ID: | NRG3_HUMAN |
| Immunogen Region: | C-Term |
| Accession Number: | NP_001010848.2 |
| Immunogen Sequence: | RNEIQRDSALTK |
| Post Translational Modifications | Proteolytic cleavage close to the plasma membrane on the external face leads to the release of the soluble growth factor form. Extensive glycosylation precedes the proteolytic cleavage. Isoform 3 is glycosylated. |
| Function | Direct ligand for the ERBB4 tyrosine kinase receptor. Binding results in ligand-stimulated tyrosine phosphorylation and activation of the receptor. Does not bind to the EGF receptor, ERBB2 or ERBB3 receptors. May be a survival factor for oligodendrocytes. |
| Protein Name | Pro-Neuregulin-3 - Membrane-Bound IsoformPro-Nrg3 Cleaved Into - Neuregulin-3Nrg-3 |
| Database Links | Reactome: R-HSA-1227986Reactome: R-HSA-1236394Reactome: R-HSA-1250196Reactome: R-HSA-1250342Reactome: R-HSA-1250347Reactome: R-HSA-1251985Reactome: R-HSA-1257604Reactome: R-HSA-1963640Reactome: R-HSA-1963642Reactome: R-HSA-2219530Reactome: R-HSA-5673001Reactome: R-HSA-6785631Reactome: R-HSA-6811558Reactome: R-HSA-8847993Reactome: R-HSA-8863795Reactome: R-HSA-9664565Reactome: R-HSA-9665686 |
| Cellular Localisation | Pro-Neuregulin-3Membrane-Bound Isoform: Cell MembraneSingle-Pass Type I Membrane ProteinDoes Not Seem To Be ActiveNeuregulin-3: SecretedIsoform 3: Cell MembraneIsoform 3 Is Also Proteolytically Released As A Soluble Form |
| Alternative Antibody Names | Anti-Pro-Neuregulin-3 - Membrane-Bound Isoform antibodyAnti-Pro-Nrg3 Cleaved Into - Neuregulin-3 antibodyAnti-Nrg-3 antibodyAnti-NRG3 antibody |
Information sourced from Uniprot.org
