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Anti-Neuregulin-3 antibody (600-720) [S9MR] (STJ11103119)

Western blot analysis of extracts of various cell lines, using Neuregulin-3 (Neuregulin-3 (NRG3) ) antibody (STJ11103119) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (STJS000856) at 1:10000 dilution. Lysates/proteins: 25 Mu g per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit. Exposure time: 180s.
Western blot analysis of extracts of various cell lines, using Neuregulin-3 (Neuregulin-3 (NRG3) ) antibody (STJ11103119) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (STJS000856) at 1:10000 dilution. Lysates/proteins: 25 Mu g per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 60s.

Anti-Neuregulin-3 antibody (600-720) [S9MR] (STJ11103119)

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STJ11103119

£146.50 - £639.50

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General Information
Product Properties
Target Information
Additional Info
Warranty Information

Host:	Rabbit
Applications:	WB
Reactivity:	Human/Mouse/Rat
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Rabbit monoclonal antibody anti-Neuregulin-3 (NRG3) (600-720) is suitable for use in Western Blot research applications.

Clonality:	Monoclonal
Clone ID:	S9MR
Conjugation:	Unconjugated
Isotype:	IgG
Formulation:	PBS with 0.02% Sodium Azide, 0.05% BSA, 50% Glycerol, pH7.3.
Purification:	Affinity purification
Dilution Range:	WB 1:500-1:1000
Storage Instruction:	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol:	NRG3
Gene ID:	10718
Uniprot ID:	NRG3_HUMAN
Immunogen Region:	600-720
Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 600-720 of human Neuregulin-3 (Neuregulin-3 (NRG3) ) (P56975).
Immunogen Sequence:	IIPSVGLEETCLQMPGISEV KSIKWCKNSYSADVVNVSIP VSDCLIAEQQEVKILLETVQ EQIRILTDARRSEDYELASV ETEDSASENTAFLPLSPTAK SEREAQFVLRNEIQRDSALT K

Tissue Specificity	Highly expressed in most regions of the brain with the exception of corpus callosum. Expressed at lower level in testis. Not detected in heart, placenta, lung, liver, skeletal muscle, kidney, pancreas, spleen, thymus, prostate, ovary, small intestine, colon and peripheral blood leukocytes.
Post Translational Modifications	Proteolytic cleavage close to the plasma membrane on the external face leads to the release of the soluble growth factor form. Extensive glycosylation precedes the proteolytic cleavage. Isoform 3 is glycosylated.
Function	Direct ligand for the ERBB4 tyrosine kinase receptor. Binding results in ligand-stimulated tyrosine phosphorylation and activation of the receptor. Does not bind to the EGF receptor, ERBB2 or ERBB3 receptors. May be a survival factor for oligodendrocytes.
Protein Name	Pro-Neuregulin-3 - Membrane-Bound Isoform Pro-Nrg3 Cleaved Into - Neuregulin-3 Nrg-3
Database Links	Reactome: R-HSA-1227986 Reactome: R-HSA-1236394 Reactome: R-HSA-1250196 Reactome: R-HSA-1250342 Reactome: R-HSA-1250347 Reactome: R-HSA-1251985 Reactome: R-HSA-1257604 Reactome: R-HSA-1963640 Reactome: R-HSA-1963642 Reactome: R-HSA-2219530 Reactome: R-HSA-5673001 Reactome: R-HSA-6785631 Reactome: R-HSA-6811558 Reactome: R-HSA-8847993 Reactome: R-HSA-8863795 Reactome: R-HSA-9664565 Reactome: R-HSA-9665686
Cellular Localisation	Pro-Neuregulin-3 Membrane-Bound Isoform: Cell Membrane Single-Pass Type I Membrane Protein Does Not Seem To Be Active Neuregulin-3: Secreted Isoform 3: Cell Membrane Isoform 3 Is Also Proteolytically Released As A Soluble Form
Alternative Antibody Names	Anti-Pro-Neuregulin-3 - Membrane-Bound Isoform antibody Anti-Pro-Nrg3 Cleaved Into - Neuregulin-3 antibody Anti-Nrg-3 antibody Anti-NRG3 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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