| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Monoclonal |
| Clone ID : | S9MR |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 0.05% BSA, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:1000 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | NRG3 |
| Gene ID: | 10718 |
| Uniprot ID: | NRG3_HUMAN |
| Immunogen Region: | 600-720 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 600-720 of human Neuregulin-3 (Neuregulin-3 (NRG3) ) (P56975). |
| Immunogen Sequence: | IIPSVGLEETCLQMPGISEV KSIKWCKNSYSADVVNVSIP VSDCLIAEQQEVKILLETVQ EQIRILTDARRSEDYELASV ETEDSASENTAFLPLSPTAK SEREAQFVLRNEIQRDSALT K |
| Tissue Specificity | Highly expressed in most regions of the brain with the exception of corpus callosum. Expressed at lower level in testis. Not detected in heart, placenta, lung, liver, skeletal muscle, kidney, pancreas, spleen, thymus, prostate, ovary, small intestine, colon and peripheral blood leukocytes. |
| Post Translational Modifications | Proteolytic cleavage close to the plasma membrane on the external face leads to the release of the soluble growth factor form. Extensive glycosylation precedes the proteolytic cleavage. Isoform 3 is glycosylated. |
| Function | Direct ligand for the ERBB4 tyrosine kinase receptor. Binding results in ligand-stimulated tyrosine phosphorylation and activation of the receptor. Does not bind to the EGF receptor, ERBB2 or ERBB3 receptors. May be a survival factor for oligodendrocytes. |
| Protein Name | Pro-Neuregulin-3 - Membrane-Bound Isoform Pro-Nrg3 Cleaved Into - Neuregulin-3 Nrg-3 |
| Database Links | Reactome: R-HSA-1227986 Reactome: R-HSA-1236394 Reactome: R-HSA-1250196 Reactome: R-HSA-1250342 Reactome: R-HSA-1250347 Reactome: R-HSA-1251985 Reactome: R-HSA-1257604 Reactome: R-HSA-1963640 Reactome: R-HSA-1963642 Reactome: R-HSA-2219530 Reactome: R-HSA-5673001 Reactome: R-HSA-6785631 Reactome: R-HSA-6811558 Reactome: R-HSA-8847993 Reactome: R-HSA-8863795 Reactome: R-HSA-9664565 Reactome: R-HSA-9665686 |
| Cellular Localisation | Pro-Neuregulin-3 Membrane-Bound Isoform: Cell Membrane Single-Pass Type I Membrane Protein Does Not Seem To Be Active Neuregulin-3: Secreted Isoform 3: Cell Membrane Isoform 3 Is Also Proteolytically Released As A Soluble Form |
| Alternative Antibody Names | Anti-Pro-Neuregulin-3 - Membrane-Bound Isoform antibody Anti-Pro-Nrg3 Cleaved Into - Neuregulin-3 antibody Anti-Nrg-3 antibody Anti-NRG3 antibody |
Information sourced from Uniprot.org