| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-Sialidase-4 is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: |
1 mg/mL |
| Dilution Range: |
WB 1:500-2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
NEU4 |
| Gene ID: |
129807 |
| Uniprot ID: |
NEUR4_HUMAN |
| Specificity: |
This antibody detects endogenous levels of NEU4 at Human, Mouse |
| Immunogen: |
Synthesized peptide derived from human NEU4 |
| Post Translational Modifications | Isoform 2: N-glycosylated. |
| Function | Exo-alpha-sialidase that catalyzes the hydrolytic cleavage of the terminal sialic acid (N-acetylneuraminic acid, Neu5Ac) of a glycan moiety in the catabolism of glycolipids, glycoproteins and oligosacharides. Efficiently hydrolyzes gangliosides including alpha-(2->3)-sialylated GD1a and GM3 and alpha-(2->8)-sialylated GD3. Hydrolyzes poly-alpha-(2->8)-sialylated neural cell adhesion molecule NCAM1 likely at growth cones, suppressing neurite outgrowth in hippocampal neurons. May desialylate sialyl Lewis A and X antigens at the cell surface, down-regulating these glycan epitopes recognized by SELE/E selectin in the initiation of cell adhesion and extravasation. Has sialidase activity toward mucin, fetuin and sialyllactose. |
| Protein Name | Sialidase-4N-Acetyl-Alpha-Neuraminidase 4 |
| Database Links | Reactome: R-HSA-1660662 Q8WWR8-2Reactome: R-HSA-4085001 |
| Cellular Localisation | Isoform 1: Cell MembranePeripheral Membrane ProteinEndoplasmic Reticulum MembraneMicrosome MembraneMitochondrion MembraneCell ProjectionNeuron ProjectionPredominantly Associates With Endoplasmic Reticulum MembranesOnly A Small Fraction Associates With Mitochondrial And Plasma MembranesIsoform 2: Mitochondrion Inner MembraneMitochondrion Outer MembraneLysosome LumenIsoform 2 Is SolubleN-Glycosylated And Found In The Lumen Of LysosomesHoweverNo Signal Sequence Nor N-Glycosylation Site Is Predicted From The Sequence |
| Alternative Antibody Names | Anti-Sialidase-4 antibodyAnti-N-Acetyl-Alpha-Neuraminidase 4 antibodyAnti-NEU4 antibodyAnti-LP5125 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
