Function | Seems to be involved in cell adhesion through trans-homophilic and -heterophilic interactions, the latter including specifically interactions with NECTIN1. Plays a role in the senescence-associated cell size enlargement via SFK/PI3K/Rac1 and thus promotes senescent cell survival. Participates also in the innate immune response by acting as a ligand for the receptor TIGIT to inhibit NK-cell activity. |
Protein Name | Nectin-4Ig Superfamily Receptor LnirNectin Cell Adhesion Molecule 4Poliovirus Receptor-Related Protein 4 |
Database Links | Reactome: R-MMU-418990Reactome: -MMU-420597 |
Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane ProteinCell JunctionAdherens JunctionColocalizes With Afdn At Cadherin-Based Adherens Junctions |
Alternative Antibody Names | Anti-Nectin-4 antibodyAnti-Ig Superfamily Receptor Lnir antibodyAnti-Nectin Cell Adhesion Molecule 4 antibodyAnti-Poliovirus Receptor-Related Protein 4 antibodyAnti-Nectin4 antibodyAnti-Lnir antibodyAnti-Prr4 antibodyAnti-Pvrl4 antibody |
Information sourced from Uniprot.org