| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-PVRL4 (32-146) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:1000-1:5000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
NECTIN4 |
| Gene ID: |
81607 |
| Uniprot ID: |
NECT4_HUMAN |
| Immunogen Region: |
32-146 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 32-146 of human PVRL4 (NP_112178.2). |
| Immunogen Sequence: |
GELETSDVVTVVLGQDAKLP CFYRGDSGEQVGQVAWARVD AGEGAQELALLHSKYGLHVS PAYEGRVEQPPPPRNPLDGS VLLRNAVQADEGEYECRVST FPAGSFQARLRLRVL |
| Tissue Specificity | Predominantly expressed in placenta. Not detected in normal breast epithelium but expressed in breast carcinoma. |
| Post Translational Modifications | The soluble form is produced by proteolytic cleavage at the cell surface (shedding), probably by ADAM17/TACE. |
| Function | Seems to be involved in cell adhesion through trans-homophilic and -heterophilic interactions, the latter including specifically interactions with NECTIN1. Does not act as receptor for alpha-herpesvirus entry into cells. (Microbial infection) Acts as a receptor for measles virus. |
| Protein Name | Nectin-4Ig Superfamily Receptor LnirNectin Cell Adhesion Molecule 4Poliovirus Receptor-Related Protein 4 Cleaved Into - Processed Poliovirus Receptor-Related Protein 4 |
| Database Links | Reactome: R-HSA-418990Reactome: R-HSA-420597 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane ProteinCell JunctionAdherens JunctionColocalizes With Afdn At Cadherin-Based Adherens JunctionsProcessed Poliovirus Receptor-Related Protein 4: SecretedThe Secreted Form Is Found In Breast Tumor Patients |
| Alternative Antibody Names | Anti-Nectin-4 antibodyAnti-Ig Superfamily Receptor Lnir antibodyAnti-Nectin Cell Adhesion Molecule 4 antibodyAnti-Poliovirus Receptor-Related Protein 4 Cleaved Into - Processed Poliovirus Receptor-Related Protein 4 antibodyAnti-NECTIN4 antibodyAnti-LNIR antibodyAnti-PRR4 antibodyAnti-PVRL4 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
