| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Rat/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-Nectin-4 (312-361) is suitable for use in Western Blot and ELISA research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | WB 1:500-1:2000 ELISA 1:5000 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | NECTIN4 |
| Gene ID: | 81607 |
| Uniprot ID: | NECT4_HUMAN |
| Immunogen Region: | 312-361 |
| Specificity: | Nectin 4 Polyclonal Antibody detects endogenous levels of Nectin 4 protein. |
| Immunogen: | The antiserum was produced against synthesized peptide derived from human PVRL4. AA range:312-361 |
| Tissue Specificity | Predominantly expressed in placenta. Not detected in normal breast epithelium but expressed in breast carcinoma. |
| Post Translational Modifications | The soluble form is produced by proteolytic cleavage at the cell surface (shedding), probably by ADAM17/TACE. |
| Function | Seems to be involved in cell adhesion through trans-homophilic and -heterophilic interactions, the latter including specifically interactions with NECTIN1. Does not act as receptor for alpha-herpesvirus entry into cells. (Microbial infection) Acts as a receptor for measles virus. |
| Protein Name | Nectin-4 Ig Superfamily Receptor Lnir Nectin Cell Adhesion Molecule 4 Poliovirus Receptor-Related Protein 4 Cleaved Into - Processed Poliovirus Receptor-Related Protein 4 |
| Database Links | Reactome: R-HSA-418990 Reactome: R-HSA-420597 |
| Cellular Localisation | Cell Membrane Single-Pass Type I Membrane Protein Cell Junction Adherens Junction Colocalizes With Afdn At Cadherin-Based Adherens Junctions Processed Poliovirus Receptor-Related Protein 4: Secreted The Secreted Form Is Found In Breast Tumor Patients |
| Alternative Antibody Names | Anti-Nectin-4 antibody Anti-Ig Superfamily Receptor Lnir antibody Anti-Nectin Cell Adhesion Molecule 4 antibody Anti-Poliovirus Receptor-Related Protein 4 Cleaved Into - Processed Poliovirus Receptor-Related Protein 4 antibody Anti-NECTIN4 antibody Anti-LNIR antibody Anti-PRR4 antibody Anti-PVRL4 antibody |
Information sourced from Uniprot.org