| Tissue Specificity | Widely expressed. Expression is most abundant in heart, liver and pancreas. |
| Function | Isoform 1: Essential bifunctional enzyme that catalyzes both the N-deacetylation and the N-sulfation of glucosamine (GlcNAc) of the glycosaminoglycan in heparan sulfate. Modifies the GlcNAc-GlcA disaccharide repeating sugar backbone to make N-sulfated heparosan, a prerequisite substrate for later modifications in heparin biosynthesis. Plays a role in determining the extent and pattern of sulfation of heparan sulfate. Participates in biosynthesis of heparan sulfate that can ultimately serve as L-selectin ligands, thereby playing a role in inflammatory response. Required for the exosomal release of SDCBP, CD63 and syndecan. Isoform 3: Lacks both N-deacetylase and N-sulfotransferase activities. Acts as a dominant negative on isoform 1, likely by changing the composition of enzyme complexes responsible for elongation and modification of heparan sulfates. |
| Protein Name | Bifunctional Heparan Sulfate N-Deacetylase/N-Sulfotransferase 1Glucosaminyl N-Deacetylase/N-Sulfotransferase 1Ndst-1N-Heparan Sulfate Sulfotransferase 1N-Hsst 1Heparan Sulfate-Glucosamine N-Sulfotransferase 1Hsnst 1 Includes - Heparan Sulfate N-Deacetylase 1 - Heparan Sulfate N-Sulfotransferase 1 |
| Database Links | Reactome: R-HSA-2022928 |
| Cellular Localisation | Isoform 1: Golgi ApparatusTrans-Golgi Network MembraneSingle-Pass Type Ii Membrane ProteinGolgi ApparatusCis-Golgi Network MembraneIsoform 3: Golgi Apparatus |
| Alternative Antibody Names | Anti-Bifunctional Heparan Sulfate N-Deacetylase/N-Sulfotransferase 1 antibodyAnti-Glucosaminyl N-Deacetylase/N-Sulfotransferase 1 antibodyAnti-Ndst-1 antibodyAnti-N-Heparan Sulfate Sulfotransferase 1 antibodyAnti-N-Hsst 1 antibodyAnti-Heparan Sulfate-Glucosamine N-Sulfotransferase 1 antibodyAnti-Hsnst 1 Includes - Heparan Sulfate N-Deacetylase 1 - Heparan Sulfate N-Sulfotransferase 1 antibodyAnti-NDST1 antibodyAnti-HSST antibodyAnti-HSST1 antibody |
Information sourced from Uniprot.org
