| Tissue Specificity | Expressed predominantly in brain and heart (at protein level). In the brain, detected in astrocytes. Isoform 1 and isoform 2 are only expressed in brain. Isoform 3 is expressed in both heart and brain. Up-regulated in glioblastoma multiforme cells. |
| Post Translational Modifications | Phosphorylated in an aortic smooth muscle cell line, following PDGF treatment. |
| Function | Contributes to the maintenance of intracerebral BDNF levels within the normal range, which is necessary for the preservation of spatial learning and the resistance to neuronal cell death caused by ischemic stress. May enhance growth factor-induced ERK1 and ERK2 phosphorylation, including that induced by PDGF and FGF. May attenuate NGF-promoted ELK1 phosphorylation in a microtubule-dependent manner. |
| Protein Name | Protein Ndrg4Brain Development-Related Molecule 1N-Myc Downstream-Regulated Gene 4 ProteinVascular Smooth Muscle Cell-Associated Protein 8Smap-8 |
| Cellular Localisation | CytoplasmCytosol |
| Alternative Antibody Names | Anti-Protein Ndrg4 antibodyAnti-Brain Development-Related Molecule 1 antibodyAnti-N-Myc Downstream-Regulated Gene 4 Protein antibodyAnti-Vascular Smooth Muscle Cell-Associated Protein 8 antibodyAnti-Smap-8 antibodyAnti-NDRG4 antibodyAnti-BDM1 antibodyAnti-KIAA1180 antibody |
Information sourced from Uniprot.org
