| Host: |
Rabbit |
| Applications: |
IHC |
| Reactivity: |
Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-NDP (25-133) is suitable for use in Immunohistochemistry research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
IHC 1:50-1:100 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
NDP |
| Gene ID: |
4693 |
| Uniprot ID: |
NDP_HUMAN |
| Immunogen Region: |
25-133 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 25-133 of human NDP (NP_000257.1). |
| Immunogen Sequence: |
KTDSSFIMDSDPRRCMRHHY VDSISHPLYKCSSKMVLLAR CEGHCSQASRSEPLVSFSTV LKQPFRSSCHCCRPQTSKLK ALRLRCSGGMRLTATYRYIL SCHCEECNS |
| Tissue Specificity | Expressed in the outer nuclear, inner nuclear and ganglion cell layers of the retina, and in fetal and adult brain. |
| Function | Activates the canonical Wnt signaling pathway through FZD4 and LRP5 coreceptor. Plays a central role in retinal vascularization by acting as a ligand for FZD4 that signals via stabilizing beta-catenin (CTNNB1) and activating LEF/TCF-mediated transcriptional programs. Acts in concert with TSPAN12 to activate FZD4 independently of the Wnt-dependent activation of FZD4, suggesting the existence of a Wnt-independent signaling that also promote accumulation the beta-catenin (CTNNB1). May be involved in a pathway that regulates neural cell differentiation and proliferation. Possible role in neuroectodermal cell-cell interaction. |
| Protein Name | NorrinNorrie Disease ProteinX-Linked Exudative Vitreoretinopathy 2 Protein |
| Cellular Localisation | Secreted |
| Alternative Antibody Names | Anti-Norrin antibodyAnti-Norrie Disease Protein antibodyAnti-X-Linked Exudative Vitreoretinopathy 2 Protein antibodyAnti-NDP antibodyAnti-EVR2 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
