| Short Description : | Rabbit polyclonal NCS1 (1-190) antibody for use in WB and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications: | WB/ELISA |
| Host: | Rabbit |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Isotype: | IgG |
| Conjugation: | Unconjugated |
| Concentration: | Lot specific |
| Purification: | Affinity purification |
| Dilution Range: | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | NCS1 |
| Gene ID: | 23413 |
| Uniprot ID: | NCS1_HUMAN |
| Immunogen Region: | 1-190 |
| Immunogen Sequence: | MGKSNSKLKPEVVEELTRKT YFTEKEVQQWYKGFIKDCPS GQLDAAGFQKIYKQFFPFGD PTKFATFVFNVFDENKDGRI EFSEFIQALSVTSRGTLDEK LRWAFKLYDLDNDGYITRNE MLDIVDAIYQMVGNTVELPE EENTPEKRVDRIFAMMDKNA DGKLTLQEFQEGSKADPSIV QALSLYDGLV |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-190 of human NCS1 (NP_055101.2). |
| Function | Neuronal calcium sensor, regulator of G protein-coupled receptor phosphorylation in a calcium dependent manner. Directly regulates GRK1 (RHOK), but not GRK2 to GRK5. Can substitute for calmodulin. Stimulates PI4KB kinase activity. Involved in long-term synaptic plasticity through its interaction with PICK1. May also play a role in neuron differentiation through inhibition of the activity of N-type voltage-gated calcium channel. |
| Protein Name | Neuronal Calcium Sensor 1Ncs-1Frequenin HomologFrequenin-Like ProteinFrequenin-Like Ubiquitous Protein |
| Database Links | |
| Cellular Localisation | Golgi ApparatusPostsynaptic DensityCytoplasmPerinuclear RegionCell MembranePeripheral Membrane ProteinMembraneLipid-AnchorAssociated With Golgi StacksPost-Synaptic Densities Of DendritesAnd In The Pre-Synaptic Nerve Terminal At Neuromuscular Junctions |
| Alternative Antibody Names | Anti-Neuronal Calcium Sensor 1 antibodyAnti-Ncs-1 antibodyAnti-Frequenin Homolog antibodyAnti-Frequenin-Like Protein antibodyAnti-Frequenin-Like Ubiquitous Protein antibodyAnti-NCS1 antibodyAnti-FLUP antibodyAnti-FREQ antibody |
Information sourced from Uniprot.org
