Host: | Rabbit |
Applications: | IHC/IF/ELISA |
Reactivity: | Human/Rat/Mouse |
Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Short Description : | Rabbit polyclonal antibody anti-Nuclear receptor coactivator 2 (702-751 aa) is suitable for use in Immunohistochemistry, Immunofluorescence and ELISA research applications. |
Clonality : | Polyclonal |
Conjugation: | Unconjugated |
Isotype: | IgG |
Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
Concentration: | 1 mg/mL |
Dilution Range: | IHC 1:100-1:300 ELISA 1:40000 IF 1:50-200 |
Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Gene Symbol: | NCOA2 |
Gene ID: | 10499 |
Uniprot ID: | NCOA2_HUMAN |
Immunogen Region: | 702-751 aa |
Specificity: | GRIP-1 Polyclonal Antibody detects endogenous levels of GRIP-1 protein. |
Immunogen: | The antiserum was produced against synthesized peptide derived from the human NCoA2 at the amino acid range 702-751 |
Function | Transcriptional coactivator for steroid receptors and nuclear receptors. Coactivator of the steroid binding domain (AF-2) but not of the modulating N-terminal domain (AF-1). Required with NCOA1 to control energy balance between white and brown adipose tissues. Critical regulator of glucose metabolism regulation, acts as a RORA coactivator to specifically modulate G6PC1 expression. Involved in the positive regulation of the transcriptional activity of the glucocorticoid receptor NR3C1 by sumoylation enhancer RWDD3. Positively regulates the circadian clock by acting as a transcriptional coactivator for the CLOCK-BMAL1 heterodimer. |
Protein Name | Nuclear Receptor Coactivator 2 Ncoa-2 Class E Basic Helix-Loop-Helix Protein 75 Bhlhe75 Transcriptional Intermediary Factor 2 Htif2 |
Database Links | Reactome: R-HSA-1368082 Reactome: R-HSA-1368108 Reactome: R-HSA-159418 Reactome: R-HSA-192105 Reactome: R-HSA-193368 Reactome: R-HSA-193807 Reactome: R-HSA-1989781 Reactome: R-HSA-211976 Reactome: R-HSA-2151201 Reactome: R-HSA-2426168 Reactome: R-HSA-3214847 Reactome: R-HSA-381340 Reactome: R-HSA-3899300 Reactome: R-HSA-400206 Reactome: R-HSA-400253 Reactome: R-HSA-5625886 Reactome: R-HSA-9018519 Reactome: R-HSA-9707564 Reactome: R-HSA-9707616 |
Cellular Localisation | Nucleus |
Alternative Antibody Names | Anti-Nuclear Receptor Coactivator 2 antibody Anti-Ncoa-2 antibody Anti-Class E Basic Helix-Loop-Helix Protein 75 antibody Anti-Bhlhe75 antibody Anti-Transcriptional Intermediary Factor 2 antibody Anti-Htif2 antibody Anti-NCOA2 antibody Anti-BHLHE75 antibody Anti-SRC2 antibody Anti-TIF2 antibody |
Information sourced from Uniprot.org