| Host: | Rabbit |
| Applications: | IHC/IF/ELISA |
| Reactivity: | Human/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-Cytoplasmic protein NCK2 (331-380) is suitable for use in Immunohistochemistry, Immunofluorescence and ELISA research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | IHC 1:100-1:300ELISA 1:10000IF 1:50-200 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | NCK2 |
| Gene ID: | 8440 |
| Uniprot ID: | NCK2_HUMAN |
| Immunogen Region: | 331-380 |
| Specificity: | Nck-2 Polyclonal Antibody detects endogenous levels of Nck-2 protein. |
| Immunogen: | The antiserum was produced against synthesized peptide derived from human NCK2. AA range:331-380 |
| Tissue Specificity | Ubiquitous. |
| Post Translational Modifications | Phosphorylated. |
| Function | Adapter protein which associates with tyrosine-phosphorylated growth factor receptors or their cellular substrates. Maintains low levels of EIF2S1 phosphorylation by promoting its dephosphorylation by PP1. Plays a role in ELK1-dependent transcriptional activation in response to activated Ras signaling. |
| Protein Name | Cytoplasmic Protein Nck2Growth Factor Receptor-Bound Protein 4Nck Adaptor Protein 2Nck-2Sh2/Sh3 Adaptor Protein Nck-Beta |
| Database Links | Reactome: R-HSA-186763Reactome: R-HSA-373753Reactome: R-HSA-3928664Reactome: R-HSA-428540Reactome: R-HSA-4420097Reactome: R-HSA-8985801Reactome: R-HSA-9013420Reactome: R-HSA-9013424 |
| Cellular Localisation | CytoplasmEndoplasmic Reticulum |
| Alternative Antibody Names | Anti-Cytoplasmic Protein Nck2 antibodyAnti-Growth Factor Receptor-Bound Protein 4 antibodyAnti-Nck Adaptor Protein 2 antibodyAnti-Nck-2 antibodyAnti-Sh2/Sh3 Adaptor Protein Nck-Beta antibodyAnti-NCK2 antibodyAnti-GRB4 antibody |
Information sourced from Uniprot.org
