| Function | Subunit of the phagocyte NADPH oxidase complex that mediates the transfer of electrons from cytosolic NADPH to O2 to produce the superoxide anion (O2(-)). In the activated complex, electrons are first transferred from NADPH to flavin adenine dinucleotide (FAD) and subsequently transferred via two heme molecules to molecular oxygen, producing superoxide through an outer-sphere reaction. Activation of the NADPH oxidase complex is initiated by the assembly of cytosolic subunits of the NADPH oxidase complex with the core NADPH oxidase complex to form a complex at the plasma membrane or phagosomal membrane. This activation process is initiated by phosphorylation dependent binding of the cytosolic NCF1/p47-phox subunit to the C-terminus of CYBA/p22-phox. |
| Protein Name | Neutrophil Cytosol Factor 2Ncf-267 Kda Neutrophil Oxidase FactorNadph Oxidase Activator 2Neutrophil Nadph Oxidase Factor 2P67-Phox |
| Database Links | Reactome: R-HSA-1222556Reactome: R-HSA-1236973Reactome: R-HSA-3299685Reactome: R-HSA-4420097Reactome: R-HSA-5668599Reactome: R-HSA-9013149Reactome: R-HSA-9013404Reactome: R-HSA-9013423 |
| Cellular Localisation | Cytoplasm |
| Alternative Antibody Names | Anti-Neutrophil Cytosol Factor 2 antibodyAnti-Ncf-2 antibodyAnti-67 Kda Neutrophil Oxidase Factor antibodyAnti-Nadph Oxidase Activator 2 antibodyAnti-Neutrophil Nadph Oxidase Factor 2 antibodyAnti-P67-Phox antibodyAnti-NCF2 antibodyAnti-NOXA2 antibodyAnti-P67PHOX antibody |
Information sourced from Uniprot.org
