| Post Translational Modifications | Acetylation on Lys-99 modulates enzymatic activity. |
| Function | Endoplasmic reticulum (ER)-membrane-bound lysine N-acetyltransferase catalyzing the N6-acetylation of lysine residues in the lumen of the ER in various proteins, including PROM1 and BACE1, using acetyl-CoA as acetyl donor. Thereby, may regulate apoptosis through the acetylation and the regulation of the expression of PROM1. Acetylates and stabilizes BACE1 immature protein, leading to increased steady-state levels in neurons. By acting on BACE1 expression, may regulate amyloid beta-peptide formation. N(6)-lysine acetylation in ER maintains protein homeostasis and regulates reticulophagy. |
| Protein Name | N-Acetyltransferase 8bAcetyltransferase 1Atase1Camello-Like Protein 2Protein-Lysine N6-Acetyltransferase 8b |
| Cellular Localisation | Endoplasmic Reticulum-Golgi Intermediate Compartment MembraneSingle-Pass Type Ii Membrane ProteinEndoplasmic Reticulum MembraneEnriched In The Endoplasmic Reticulum-Golgi Intermediate Compartment (Ergic) |
| Alternative Antibody Names | Anti-N-Acetyltransferase 8b antibodyAnti-Acetyltransferase 1 antibodyAnti-Atase1 antibodyAnti-Camello-Like Protein 2 antibodyAnti-Protein-Lysine N6-Acetyltransferase 8b antibodyAnti-NAT8B antibodyAnti-CML2 antibody |
Information sourced from Uniprot.org
![Western blot analysis of lysates from wild type (WT) and ISG15 Rabbit polyclonal antibody knockdown (KD) HeLa cells, using [KD Validated] ISG15 Rabbit polyclonal antibody (STJ11104641) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (STJS000856) at 1:10000 dilution. Lysates/proteins: 25 Mu g per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 10s.](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/600x533/products/177285/368924/STJ11104641_1__76093.1713134403.jpg?c=1 "Western blot analysis of lysates from wild type (WT) and ISG15 Rabbit polyclonal antibody knockdown (KD) HeLa cells, using [KD Validated] ISG15 Rabbit polyclonal antibody (STJ11104641) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (STJS000856) at 1:10000 dilution. Lysates/proteins: 25 Mu g per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 10s.")
