Anti-NAT8B antibody (75-165) (STJ29283)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal NAT8B (75-165) antibody for use in WB, IHC-P and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC-P/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000IHC-P:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | NAT8BUniprot ID=NAT8B_HUMAN" |
| Immunogen Region | 75-165 |
| Immunogen Sequence | WFLAKKPWTRYVDIALRTDM SDITKSYLSECGSCFWVGES EEKVVGTVGALPVDDPTLRE KRLQLFHLSVDNEHRGQGIA KALVRTVLQFA |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 75-165 of human NAT8B (NP_057431.2). |
Additional Info
| Post Translational Modifications | Acetylation on Lys-99 modulates enzymatic activity. |
| Function | Endoplasmic reticulum (ER)-membrane-bound lysine N-acetyltransferase catalyzing the N6-acetylation of lysine residues in the lumen of the ER in various proteins, including PROM1 and BACE1, using acetyl-CoA as acetyl donor. Thereby, may regulate apoptosis through the acetylation and the regulation of the expression of PROM1. Acetylates and stabilizes BACE1 immature protein, leading to increased steady-state levels in neurons. By acting on BACE1 expression, may regulate amyloid beta-peptide formation. N(6)-lysine acetylation in ER maintains protein homeostasis and regulates reticulophagy. |
| Protein Name | N-Acetyltransferase 8bAcetyltransferase 1Atase1Camello-Like Protein 2Protein-Lysine N6-Acetyltransferase 8b |
| Cellular Localisation | Endoplasmic Reticulum-Golgi Intermediate Compartment MembraneSingle-Pass Type Ii Membrane ProteinEndoplasmic Reticulum MembraneEnriched In The Endoplasmic Reticulum-Golgi Intermediate Compartment (Ergic) |
| Alternative Antibody Names | Anti-N-Acetyltransferase 8b antibodyAnti-Acetyltransferase 1 antibodyAnti-Atase1 antibodyAnti-Camello-Like Protein 2 antibodyAnti-Protein-Lysine N6-Acetyltransferase 8b antibodyAnti-NAT8B antibodyAnti-CML2 antibody |
Information sourced from Uniprot.org