| Host: | Goat |
| Applications: | Pep-ELISA/WB-Trf |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Goat polyclonal antibody anti-NALP2/PAN1 (C-Term) is suitable for use in ELISA and Western Blot research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Purification: | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Concentration: | 0.5 mg/mL |
| Dilution Range: | Peptide ELISA: antibody detection limit dilution 1:16000.WB: In transfected HEK293 transiently expressing full-length Human NLRP2 (myc and DYKDDDDK tagged) , a band of approx. 150kDa was observed. No bands were observed in mock-transfected HEK29 |
| Storage Instruction: | Store at-20°C on receipt and minimise freeze-thaw cycles. |
| Gene Symbol: | NLRP2 |
| Gene ID: | 55655 |
| Uniprot ID: | NALP2_HUMAN |
| Immunogen Region: | C-Term |
| Accession Number: | NP_060322.1 |
| Immunogen Sequence: | KNPQLIIDTEKHHP |
| Function | Suppresses TNF- and CD40-induced NFKB1 activity at the level of the IKK complex, by inhibiting NFKBIA degradation induced by TNF. When associated with PYCARD, activates CASP1, leading to the secretion of mature pro-inflammatory cytokine IL1B. May be a component of the inflammasome, a protein complex which also includes PYCARD, CARD8 and CASP1 and whose function would be the activation of pro-inflammatory caspases. |
| Protein Name | Nacht - Lrr And Pyd Domains-Containing Protein 2Nucleotide-Binding Site Protein 1Pyrin Domain And Nacht Domain-Containing Protein 1Pyrin-Containing Apaf1-Like Protein 2 |
| Cellular Localisation | Cytoplasm |
| Alternative Antibody Names | Anti-Nacht - Lrr And Pyd Domains-Containing Protein 2 antibodyAnti-Nucleotide-Binding Site Protein 1 antibodyAnti-Pyrin Domain And Nacht Domain-Containing Protein 1 antibodyAnti-Pyrin-Containing Apaf1-Like Protein 2 antibodyAnti-NLRP2 antibodyAnti-NALP2 antibodyAnti-NBS1 antibodyAnti-PAN1 antibodyAnti-PYPAF2 antibody |
Information sourced from Uniprot.org