| Host: | Goat |
| Applications: | Pep-ELISA/IF/FC |
| Reactivity: | Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Goat polyclonal antibody anti-Nalp10/Nlrp10-Mouse (N-Term) is suitable for use in ELISA, Immunofluorescence and Flow Cytometry research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Purification: | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Concentration: | 0.5 mg/mL |
| Dilution Range: | Peptide ELISA: antibody detection limit dilution 1:128000.IF: Strong expression of the protein seen in the cytoplasm of NIH3T3 cells. Recommended concentration: 10µg/ml. FC:Flow cytometric analysis of NIH3T3 cells. Recommended concentration: 1 |
| Storage Instruction: | Store at-20°C on receipt and minimise freeze-thaw cycles. |
| Immunogen Region: | N-Term |
| Accession Number: | NP_780741.1 |
| Immunogen Sequence: | NDLEENSFKTLKFH |
| Function | Inhibits autoprocessing of CASP1, CASP1-dependent IL1B secretion, PYCARD aggregation and PYCARD-mediated apoptosis but not apoptosis induced by FAS or BID. Displays anti-inflammatory activity. Required for immunity against C.albicans infection. Involved in the innate immune response by contributing to proinflammatory cytokine release in response to invasive bacterial infection. Contributes to T-cell-mediated inflammatory responses in the skin. Plays a role in protection against periodontitis through its involvement in induction of IL1A via ERK activation in oral epithelial cells infected with periodontal pathogens. Exhibits both ATPase and GTPase activities. |
| Protein Name | Nacht - Lrr And Pyd Domains-Containing Protein 10 |
| Cellular Localisation | CytoplasmCell MembranePeripheral Membrane ProteinCytoplasmic Protein Which Is Recruited To The Cell Membrane By Nod1 Following Invasive Bacterial Infection |
| Alternative Antibody Names | Anti-Nacht - Lrr And Pyd Domains-Containing Protein 10 antibodyAnti-Nlrp10 antibodyAnti-Nalp10 antibodyAnti-Pynod antibody |
Information sourced from Uniprot.org