| Function | Component of the SOSS complex, a multiprotein complex that functions downstream of the MRN complex to promote DNA repair and G2/M checkpoint. In the SOSS complex, acts as a sensor of single-stranded DNA that binds to single-stranded DNA, in particular to polypyrimidines. The SOSS complex associates with DNA lesions and influences diverse endpoints in the cellular DNA damage response including cell-cycle checkpoint activation, recombinational repair and maintenance of genomic stability. Required for efficient homologous recombination-dependent repair of double-strand breaks (DSBs) and ATM-dependent signaling pathways. |
| Protein Name | Soss Complex Subunit B1Nucleic Acid-Binding Protein 2Oligonucleotide/Oligosaccharide-Binding Fold-Containing Protein 2bSensor Of Single-Strand Dna Complex Subunit B1Sensor Of Ssdna Subunit B1Soss-B1Single-Stranded Dna-Binding Protein 1Hssb1 |
| Database Links | Reactome: R-HSA-6807505 |
| Cellular Localisation | NucleusLocalizes To Nuclear Foci Following Dna DamageFoci Formation Is Not Cell-Cycle DependentPartial Colocalization With Rad51 After Ionizing Radiation Treatment |
| Alternative Antibody Names | Anti-Soss Complex Subunit B1 antibodyAnti-Nucleic Acid-Binding Protein 2 antibodyAnti-Oligonucleotide/Oligosaccharide-Binding Fold-Containing Protein 2b antibodyAnti-Sensor Of Single-Strand Dna Complex Subunit B1 antibodyAnti-Sensor Of Ssdna Subunit B1 antibodyAnti-Soss-B1 antibodyAnti-Single-Stranded Dna-Binding Protein 1 antibodyAnti-Hssb1 antibodyAnti-NABP2 antibodyAnti-OBFC2B antibodyAnti-SSB1 antibodyAnti-LP3587 antibody |
Information sourced from Uniprot.org
