| Function | Component of the SOSS complex, a multiprotein complex that functions downstream of the MRN complex to promote DNA repair and G2/M checkpoint. In the SOSS complex, acts as a sensor of single-stranded DNA that binds to single-stranded DNA, in particular to polypyrimidines. The SOSS complex associates with DNA lesions and influences diverse endpoints in the cellular DNA damage response including cell-cycle checkpoint activation, recombinational repair and maintenance of genomic stability. Required for efficient homologous recombination-dependent repair of double-strand breaks (DSBs) and ATM-dependent signaling pathways. |
| Protein Name | Soss Complex Subunit B2Nucleic Acid-Binding Protein 1Oligonucleotide/Oligosaccharide-Binding Fold-Containing Protein 2aSensor Of Single-Strand Dna Complex Subunit B2Sensor Of Ssdna Subunit B2Soss-B2Single-Stranded Dna-Binding Protein 2Hssb2 |
| Database Links | Reactome: R-HSA-6807505 |
| Cellular Localisation | NucleusLocalizes To Nuclear Foci Following Dna Damage |
| Alternative Antibody Names | Anti-Soss Complex Subunit B2 antibodyAnti-Nucleic Acid-Binding Protein 1 antibodyAnti-Oligonucleotide/Oligosaccharide-Binding Fold-Containing Protein 2a antibodyAnti-Sensor Of Single-Strand Dna Complex Subunit B2 antibodyAnti-Sensor Of Ssdna Subunit B2 antibodyAnti-Soss-B2 antibodyAnti-Single-Stranded Dna-Binding Protein 2 antibodyAnti-Hssb2 antibodyAnti-NABP1 antibodyAnti-OBFC2A antibodyAnti-SSB2 antibody |
Information sourced from Uniprot.org
