| Host: | Rabbit |
| Applications: | WB/IF/ICC/ELISA |
| Reactivity: | Human/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000 IF/ICC:1:50-1:200 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | MYO5B |
| Gene ID: | 4645 |
| Uniprot ID: | MYO5B_HUMAN |
| Immunogen Region: | 1440-1690 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1440-1690 of human MYO5B (NP_001073936.1). |
| Immunogen Sequence: | AQALAQSERKRHELNRQVTV QRKEKDFQGMLEYHKEDEAL LIRNLVTDLKPQMLSGTVPC LPAYILYMCIRHADYTNDDL KVHSLLTSTINGIKKVLKKH NDDFEMTSFWLSNTCRLLHC LKQYSGDEGFMTQNTAKQNE HCLKNFDLTEYRQVLSDLSI QIYQQLIKIAEGVLQPMIVS AMLENESIQGLSGVKPTGYR KRSSSMADGDNSYCLEAIIR QMNAFHTVMCDQGLDPEII |
| Function | May be involved in vesicular trafficking via its association with the CART complex. The CART complex is necessary for efficient transferrin receptor recycling but not for EGFR degradation. Required in a complex with RAB11A and RAB11FIP2 for the transport of NPC1L1 to the plasma membrane. Together with RAB11A participates in CFTR trafficking to the plasma membrane and TF (transferrin) recycling in nonpolarized cells. Together with RAB11A and RAB8A participates in epithelial cell polarization. Together with RAB25 regulates transcytosis. Required for proper localization of bile salt export pump ABCB11 at the apical/canalicular plasma membrane of hepatocytes. |
| Protein Name | Unconventional Myosin-Vb |
| Database Links | Reactome: R-HSA-432040 |
| Cellular Localisation | Cytoplasm |
| Alternative Antibody Names | Anti-Unconventional Myosin-Vb antibody Anti-MYO5B antibody Anti-KIAA1119 antibody |
Information sourced from Uniprot.org