![Anti-Myelin Basic Protein antibody [SM0466] (STJA0010466)](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/124x110/products/180363/404094/STJA0010466_7__06455.1738951056.jpg?c=1 "Anti-Myelin Basic Protein antibody [SM0466] (STJA0010466)")
![Anti-Myelin Basic Protein antibody [SM0466] (STJA0010466)](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/124x110/products/180363/404095/STJA0010466_8__83066.1738951057.jpg?c=1 "Anti-Myelin Basic Protein antibody [SM0466] (STJA0010466)")
Anti-Myelin Basic Protein antibody [SM0466] (STJA0010466)
SPECIFICATIONS
ClonalityMonoclonal
HostMouse
ConjugationUnconjugated
IsotypeIgG
ImmunogenKLH conjugated Synthetic peptide corresponding to Mouse Myelin Basic Protein
General Information
| Short Description | Mouse monoclonal anti-Myelin Basic Protein for use in WB, IHC and IF in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC/IF |
| Host | Mouse |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | SM0466 |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Purification | Affinity purification |
| Dilution Range | WB (H, M, R) 1:2000-1:4000IHC/IF (H, M, R, Mk) 1:250-1:1000 |
| Formulation | PBS with 0.02% sodium azide, 100 Mu g/ml BSA and 50% glycerol. |
| Storage Instruction | Store at-20C for up to one year, and avoid repeated freeze-thaw cycles. |
Target Information
| Gene Symbol | Mbp |
| Gene ID | 17196 |
| Uniprot ID | MBP_MOUSE |
| Immunogen | KLH conjugated Synthetic peptide corresponding to Mouse Myelin Basic Protein |
Additional Info
| Post Translational Modifications | As in other animals, several charge isomers may be produced as a result of optional post-translational modifications, such as phosphorylation of serine or threonine residues, deamidation of glutamine or asparagine residues, citrullination and methylation of arginine residues. Methylated on arginine residues.decreases with the age of the animal, making MBP more cationic. Phosphorylated by TAOK2, VRK2, MAPK11, MAPK12, MAPK14 and MINK1. Proteolytically cleaved in B cell lysosomes by cathepsin CTSG which degrades the major immunogenic MBP epitope and prevents the activation of MBP-specific autoreactive T cells. |
| Function | The classic group of MBP isoforms (isoform 4-isoform 13) are with PLP the most abundant protein components of the myelin membrane in the CNS. They have a role in both its formation and stabilization. The non-classic group of MBP isoforms (isoform 1-isoform 3/Golli-MBPs) may preferentially have a role in the early developing brain long before myelination, maybe as components of transcriptional complexes, and may also be involved in signaling pathways in T-cells and neural cells. Differential splicing events combined to optional post-translational modifications give a wide spectrum of isomers, with each of them potentially having a specialized function. |
| Protein Name | Myelin Basic ProteinMbpMyelin A1 Protein |
| Database Links | |
| Cellular Localisation | Isoform 13: Myelin MembranePeripheral Membrane ProteinCytoplasmic SideIsoform 12: Myelin MembraneIsoform 11: Myelin MembraneIsoform 10: Myelin MembraneIsoform 9: Myelin MembraneIsoform 8: Myelin MembraneIsoform 7: Myelin MembraneIsoform 6: Myelin MembraneIsoform 5: Myelin MembraneIsoform 4: Myelin MembraneIsoform 3: CytoplasmNucleusIsoform 2: CytoplasmIsoform 1: Cytoplasm |
| Alternative Antibody Names | Anti-Myelin Basic Protein antibodyAnti-Mbp antibodyAnti-Myelin A1 Protein antibodyAnti-Mbp antibodyAnti-Shi antibody |
Information sourced from Uniprot.org