| Host: | Rabbit |
| Applications: | WB/IHC-P/ELISA |
| Reactivity: | Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000IHC-P:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | MYBPC3 |
| Gene ID: | 4607 |
| Uniprot ID: | MYPC3_HUMAN |
| Immunogen Region: | 200-400 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 200-400 of human MYBPC3 (NP_000247.2). |
| Immunogen Sequence: | SSKVGQHLQLHDSYDRASKV YLFELHITDAQPAFTGSYRC EVSTKDKFDCSNFNLTVHEA MGTGDLDLLSAFRRTSLAGG GRRISDSHEDTGILDFSSLL KKRDSFRTPRDSKLEAPAEE DVWEILRQAPPSEYERIAFQ YGVTDLRGMLKRLKGMRRDE KKSTAFQKKLEPAYQVSKGH KIRLTVELADHDAEVKWLKN G |
| Post Translational Modifications | Substrate for phosphorylation by PKA and PKC. Reversible phosphorylation appears to modulate contraction. Polyubiquitinated. |
| Function | Thick filament-associated protein located in the crossbridge region of vertebrate striated muscle a bands. In vitro it binds MHC, F-actin and native thin filaments, and modifies the activity of actin-activated myosin ATPase. It may modulate muscle contraction or may play a more structural role. |
| Protein Name | Myosin-Binding Protein C - Cardiac-TypeCardiac Mybp-CC-Protein - Cardiac Muscle Isoform |
| Database Links | Reactome: R-HSA-390522 |
| Alternative Antibody Names | Anti-Myosin-Binding Protein C - Cardiac-Type antibodyAnti-Cardiac Mybp-C antibodyAnti-C-Protein - Cardiac Muscle Isoform antibodyAnti-MYBPC3 antibody |
Information sourced from Uniprot.org