| Host: | Rabbit |
| Applications: | WB/IHC |
| Reactivity: | Human/Rat/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal anti-Interferon-induced GTP-binding protein Mx2 (Internal) for use in WB and IHC in Human, Rat and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | WB 1:500-2000IHC-p 1:50-300 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | MX2 |
| Gene ID: | 4600 |
| Uniprot ID: | MX2_HUMAN |
| Immunogen Region: | Internal |
| Specificity: | MxB Polyclonal Antibody detects endogenous levels of MxB protein. |
| Immunogen: | Synthesized peptide derived from the Internal region of human MxB. |
| Function | Interferon-induced dynamin-like GTPase with potent antiviral activity against human immunodeficiency virus type 1 (HIV-1). Acts by targeting the viral capsid and affects the nuclear uptake and/or stability of the HIV-1 replication complex and the subsequent chromosomal integration of the proviral DNA. Exhibits antiviral activity also against simian immunodeficiency virus (SIV-mnd). May play a role in regulating nucleocytoplasmic transport and cell-cycle progression. |
| Protein Name | Interferon-Induced Gtp-Binding Protein Mx2Interferon-Regulated Resistance Gtp-Binding Protein MxbMyxovirus Resistance Protein 2P78-Related Protein |
| Database Links | Reactome: R-HSA-1169408Reactome: R-HSA-909733 |
| Cellular Localisation | CytoplasmNucleusNuclear Pore ComplexLocalization To Nuclear Pores Requires Gtp-Binding |
| Alternative Antibody Names | Anti-Interferon-Induced Gtp-Binding Protein Mx2 antibodyAnti-Interferon-Regulated Resistance Gtp-Binding Protein Mxb antibodyAnti-Myxovirus Resistance Protein 2 antibodyAnti-P78-Related Protein antibodyAnti-MX2 antibody |
Information sourced from Uniprot.org
