| Short Description : | Rabbit polyclonal Mucin-6 (33-298 aa) antibody for use in WB and ELISA in human and mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications: | WB/ELISA |
| Host: | Rabbit |
| Reactivity: | Human/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Isotype: | IgG |
| Conjugation: | Unconjugated |
| Concentration: | Lot specific |
| Purification: | Affinity purification |
| Dilution Range: | WB:1:1000-1:5000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | MUC6 |
| Gene ID: | 4588 |
| Uniprot ID: | MUC6_HUMAN |
| Immunogen Region: | 33-298 aa |
| Immunogen Sequence: | KDSPQTAPDKGQCSTWGAGH FSTFDHHVYDFSGTCNYIFA ATCKDAFPTFSVQLRRGPDG SISRIIVELGASVVTVSEAI ISVKDIGVISLPYTSNGLQI TPFGQSVRLVAKQLELELEV VWGPDSHLMVLVERKYMGQM CGLCGNFDGKVTNEFVSEEG KFLEPHKFAALQKLDDPGEI CTFQDIPSTHVRQAQHARIC TQLLTLVAPECSVSKEPFVL SCQADVAAAPQPGPQNSSC |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 33-298 of human MUC6. (NP_005952.2). |
| Tissue Specificity | Expressed in the regenerative zone of gastric antrum, gastric body mucosa and gastric incisura mucosa. Expressed in the deeper mucous glands of gastric antrum. Overexpressed in Helicobacter pylori infected gastric epithelium. Highly expressed in duodenal Brunner's glands, gall bladder, seminal vesicle, pancreatic centroacinar cells and ducts, and periductal glands of the common bile duct. |
| Post Translational Modifications | O-glycosylated. |
| Function | May provide a mechanism for modulation of the composition of the protective mucus layer related to acid secretion or the presence of bacteria and noxious agents in the lumen. Plays an important role in the cytoprotection of epithelial surfaces and are used as tumor markers in a variety of cancers. May play a role in epithelial organogenesis. |
| Protein Name | Mucin-6Muc-6Gastric Mucin-6 |
| Database Links | Reactome: R-HSA-5083625Reactome: R-HSA-5083632Reactome: R-HSA-5083636Reactome: R-HSA-5621480Reactome: R-HSA-913709Reactome: R-HSA-977068 |
| Cellular Localisation | Secreted |
| Alternative Antibody Names | Anti-Mucin-6 antibodyAnti-Muc-6 antibodyAnti-Gastric Mucin-6 antibodyAnti-MUC6 antibody |
Information sourced from Uniprot.org
