| Short Description : | Rabbit monoclonal MTHFR (363-656 aa) antibody for use in WB and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications: | WB/ELISA |
| Host: | Rabbit |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Monoclonal |
| Clone ID : | SRM5415 |
| Isotype: | IgG |
| Conjugation: | Unconjugated |
| Concentration: | Lot specific |
| Purification: | Affinity purification |
| Dilution Range: | WB:1:1000-1:4000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation: | PBS with 0.09% Sodium Azide, 0.05% BSA, 50% Glycerol, pH 7.3. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | MTHFR |
| Gene ID: | 4524 |
| Uniprot ID: | MTHR_HUMAN |
| Immunogen Region: | 363-656 aa |
| Immunogen Sequence: | RPIFWASRPKSYIYRTQEWD EFPNGRWGNSSSPAFGELKD YYLFYLKSKSPKEELLKMWG EELTSEESVFEVFVLYLSGE PNRNGHKVTCLPWNDEPLAA ETSLLKEELLRVNRQGILTI NSQPNINGKPSSDPIVGWGP SGGYVFQKAYLEFFTSRETA EALLQVLKKYELRVNYHLVN VKGENITNAPELQPNAVTWG IFPGREIIQPTVVDPVSFMF WKDEAFALWIERWGKLYEE |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 363-656 of human MTHFR (NP_005948.3). |
| Post Translational Modifications | Phosphorylation of an N-terminal serine-rich phosphorylation region increases sensitivity to S-adenosylmethionine and inhibition. |
| Function | Catalyzes the conversion of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate, a cosubstrate for homocysteine remethylation to methionine. Represents a key regulatory connection between the folate and methionine cycles (Probable). |
| Protein Name | Methylenetetrahydrofolate ReductaseNadph |
| Database Links | Reactome: R-HSA-196757 |
| Cellular Localisation | |
| Alternative Antibody Names | Anti-Methylenetetrahydrofolate Reductase antibodyAnti-Nadph antibodyAnti-MTHFR antibody |
Information sourced from Uniprot.org
