| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | MTBP |
| Gene ID: | 27085 |
| Uniprot ID: | MTBP_HUMAN |
| Immunogen Region: | 1-300 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-300 of human MTBP (NP_071328.2). |
| Immunogen Sequence: | MDRYLLLVIWGEGKFPSAAS REAEHGPEVSSGEGTENQPD FTAANVYHLLKRSISASINP EDSTFPACSVGGIPGSKKWF FAVQAIYGFYQFCSSDWQEI HFDTEKDKIEDVLQTNIEEC LGAVECFEEEDSNSRESLSL ADLYEEAAENLHQLSDKLPA PGRAMVDIILLLSDKDPPKL KDYLPTVGALKHLREWYSAK ITIAGNHCEINCQKIAEYLS ANVVSLEDLRNVIDSKELW |
| Function | Inhibits cell migration in vitro and suppresses the invasive behavior of tumor cells. May play a role in MDM2-dependent p53/TP53 homeostasis in unstressed cells. Inhibits autoubiquitination of MDM2, thereby enhancing MDM2 stability. This promotes MDM2-mediated ubiquitination of p53/TP53 and its subsequent degradation. |
| Protein Name | Mdm2-Binding ProteinHmtbp |
| Alternative Antibody Names | Anti-Mdm2-Binding Protein antibodyAnti-Hmtbp antibodyAnti-MTBP antibody |
Information sourced from Uniprot.org