| Function | Catalyzes the reduction of N-oxygenated molecules, acting as a counterpart of cytochrome P450 and flavin-containing monooxygenases in metabolic cycles. As a component of prodrug-converting system, reduces a multitude of N-hydroxylated prodrugs particularly amidoximes, leading to increased drug bioavailability. May be involved in mitochondrial N(omega)-hydroxy-L-arginine (NOHA) reduction, regulating endogenous nitric oxide levels and biosynthesis. Postulated to cleave the N-OH bond of N-hydroxylated substrates in concert with electron transfer from NADH to cytochrome b5 reductase then to cytochrome b5, the ultimate electron donor that primes the active site for substrate reduction. |
| Protein Name | Mitochondrial Amidoxime Reducing Component 2Marc2Molybdenum Cofactor Sulfurase C-Terminal Domain-Containing Protein 2Mosc Domain-Containing Protein 2Moco Sulfurase C-Terminal Domain-Containing Protein 2 |
| Database Links | Reactome: R-HSA-211945 |
| Cellular Localisation | Mitochondrion Outer MembranePeripheral Membrane ProteinPeroxisome |
| Alternative Antibody Names | Anti-Mitochondrial Amidoxime Reducing Component 2 antibodyAnti-Marc2 antibodyAnti-Molybdenum Cofactor Sulfurase C-Terminal Domain-Containing Protein 2 antibodyAnti-Mosc Domain-Containing Protein 2 antibodyAnti-Moco Sulfurase C-Terminal Domain-Containing Protein 2 antibodyAnti-MTARC2 antibodyAnti-MARC2 antibodyAnti-MOSC2 antibody |
Information sourced from Uniprot.org
