Host: | Rabbit |
Applications: | WB/IF/ICC/ELISA |
Reactivity: | Human/Mouse/Rat |
Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Clonality: | Polyclonal |
Conjugation: | Unconjugated |
Isotype: | IgG |
Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
Purification: | Affinity purification |
Concentration: | Lot specific |
Dilution Range: | WB:1:100-1:500 IF/ICC:1:50-1:200 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Gene Symbol: | MTAP |
Gene ID: | 4507 |
Uniprot ID: | MTAP_HUMAN |
Immunogen Region: | 1-283 |
Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-283 of human MTAP (NP_002442.2). |
Immunogen Sequence: | MASGTTTTAVKIGIIGGTGL DDPEILEGRTEKYVDTPFGK PSDALILGKIKNVDCVLLAR HGRQHTIMPSKVNYQANIWA LKEEGCTHVIVTTACGSLRE EIQPGDIVIIDQFIDRTTMR PQSFYDGSHSCARGVCHIPM AEPFCPKTREVLIETAKKLG LRCHSKGTMVTIEGPRFSSR AESFMFRTWGADVINMTTVP EVVLAKEAGICYASIAMATD YDCWKEHEEAVSVDRVLKT |
Tissue Specificity | Ubiquitously expressed. |
Function | Catalyzes the reversible phosphorylation of S-methyl-5'-thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates. |
Protein Name | S-Methyl-5'-Thioadenosine Phosphorylase 5'-Methylthioadenosine Phosphorylase Mta Phosphorylase Mtap Mtapase |
Database Links | Reactome: R-HSA-1237112 Reactome: R-HSA-8950505 |
Cellular Localisation | Cytoplasm Nucleus |
Alternative Antibody Names | Anti-S-Methyl-5'-Thioadenosine Phosphorylase antibody Anti-5'-Methylthioadenosine Phosphorylase antibody Anti-Mta Phosphorylase antibody Anti-Mtap antibody Anti-Mtapase antibody Anti-MTAP antibody Anti-MSAP antibody |
Information sourced from Uniprot.org