| Host: | Rabbit |
| Applications: | WB/IF/ICC/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality: | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:100-1:500 IF/ICC:1:50-1:200 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | MTAP |
| Gene ID: | 4507 |
| Uniprot ID: | MTAP_HUMAN |
| Immunogen Region: | 1-283 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-283 of human MTAP (NP_002442.2). |
| Immunogen Sequence: | MASGTTTTAVKIGIIGGTGL DDPEILEGRTEKYVDTPFGK PSDALILGKIKNVDCVLLAR HGRQHTIMPSKVNYQANIWA LKEEGCTHVIVTTACGSLRE EIQPGDIVIIDQFIDRTTMR PQSFYDGSHSCARGVCHIPM AEPFCPKTREVLIETAKKLG LRCHSKGTMVTIEGPRFSSR AESFMFRTWGADVINMTTVP EVVLAKEAGICYASIAMATD YDCWKEHEEAVSVDRVLKT |
| Tissue Specificity | Ubiquitously expressed. |
| Function | Catalyzes the reversible phosphorylation of S-methyl-5'-thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates. |
| Protein Name | S-Methyl-5'-Thioadenosine Phosphorylase 5'-Methylthioadenosine Phosphorylase Mta Phosphorylase Mtap Mtapase |
| Database Links | Reactome: R-HSA-1237112 Reactome: R-HSA-8950505 |
| Cellular Localisation | Cytoplasm Nucleus |
| Alternative Antibody Names | Anti-S-Methyl-5'-Thioadenosine Phosphorylase antibody Anti-5'-Methylthioadenosine Phosphorylase antibody Anti-Mta Phosphorylase antibody Anti-Mtap antibody Anti-Mtapase antibody Anti-MTAP antibody Anti-MSAP antibody |
Information sourced from Uniprot.org
