| Function | Non-catalytic component of the MSL histone acetyltransferase complex, a multiprotein complex that mediates the majority of histone H4 acetylation at 'Lys-16' (H4K16ac), an epigenetic mark that prevents chromatin compaction. The MSL complex is required for chromosome stability and genome integrity by maintaining homeostatic levels of H4K16ac. The MSL complex is also involved in gene dosage by promoting up-regulation of genes expressed by the X chromosome. X up-regulation is required to compensate for autosomal biallelic expression. The MSL complex also participates in gene dosage compensation by promoting expression of Tsix non-coding RNA. Acts as a histone reader that specifically recognizes and binds histone H4 monomethylated at 'Lys-20' (H4K20Me1) in a DNA-dependent manner and is proposed to be involved in chromosomal targeting of the MSL complex. May play a role X inactivation in females. |
| Protein Name | Msl Complex Subunit 3Male-Specific Lethal 3 HomologMale-Specific Lethal-3 Homolog 1Male-Specific Lethal-3 Protein-Like 1Msl3-Like 1 |
| Database Links | Reactome: R-HSA-3214847 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Msl Complex Subunit 3 antibodyAnti-Male-Specific Lethal 3 Homolog antibodyAnti-Male-Specific Lethal-3 Homolog 1 antibodyAnti-Male-Specific Lethal-3 Protein-Like 1 antibodyAnti-Msl3-Like 1 antibodyAnti-MSL3 antibodyAnti-MSL3L1 antibody |
Information sourced from Uniprot.org
