| Host: |
Rat |
| Applications: |
ICC/IHC-F/WB/FC |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rat monoclonal antibody anti-MRP4 is suitable for use in Immunocytochemistry, Immunohistochemistry, Western Blot and Flow Cytometry research applications. |
| Clonality: |
Monoclonal |
| Clone ID: |
M4I-10 |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG2a |
| Formulation: |
Tissue culture supernatant with 0.1% BSA and 0.09% sodium azide |
| Purification: |
Protein G purified |
| Concentration: |
100 ug/mL |
| Dilution Range: |
ICC 1:20-1:50IHC 1:20WB 1:20-1:50 |
| Storage Instruction: |
Store at 2-8°C upon receipt. |
| Gene Symbol: |
ABCC4 |
| Gene ID: |
10257 |
| Uniprot ID: |
MRP4_HUMAN |
| Immunogen: |
Maltose Binding Protein and aa 372-431 of MRP4 |
| Tissue Specificity | Widely expressed, with particularly high levels in prostate, but is barely detectable in liver. sinusoidal membrane of hepatocytes. |
| Post Translational Modifications | N-glycosylated.leading to substrate-selective effects on its transport activity. |
| Function | ATP-dependent transporter of the ATP-binding cassette (ABC) family that actively extrudes physiological compounds and xenobiotics from cells. Transports a range of endogenous molecules that have a key role in cellular communication and signaling, including cyclic nucleotides such as cyclic AMP (cAMP) and cyclic GMP (cGMP), bile acids, steroid conjugates, urate, and prostaglandins. Mediates the ATP-dependent efflux of glutathione conjugates such as leukotriene C4 (LTC4) and leukotriene B4 (LTB4) too. The presence of GSH is necessary for the ATP-dependent transport of LTB4, whereas GSH is not required for the transport of LTC4. Mediates the cotransport of bile acids with reduced glutathione (GSH). Transports a wide range of drugs and their metabolites, including anticancer, antiviral and antibiotics molecules. Confers resistance to anticancer agents such as methotrexate. |
| Protein Name | Atp-Binding Cassette Sub-Family C Member 4 Mrp/Cmoat-Related Abc TransporterMulti-Specific Organic Anion Transporter BMoat-BMultidrug Resistance-Associated Protein 4 |
| Database Links | Reactome: R-HSA-114608Reactome: R-HSA-382556Reactome: R-HSA-9748787Reactome: R-HSA-9753281 |
| Cellular Localisation | Basolateral Cell MembraneMulti-Pass Membrane ProteinApical Cell MembraneIts Localization To The Basolateral Or Apical Membranes Is Tissue-Dependent |
| Alternative Antibody Names | Anti-Atp-Binding Cassette Sub-Family C Member 4 antibodyAnti-Mrp/Cmoat-Related Abc Transporter antibodyAnti-Multi-Specific Organic Anion Transporter B antibodyAnti-Moat-B antibodyAnti-Multidrug Resistance-Associated Protein 4 antibodyAnti-ABCC4 antibodyAnti-MOATB antibodyAnti-MRP4 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
