| Host: |
Rabbit |
| Applications: |
ELISA/IHC/IP/WB |
| Reactivity: |
Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-MRP1 is suitable for use in ELISA, Immunohistochemistry, Immunoprecipitation and Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Contains Tris, HCl/Glycine buffer pH 7.4-7.8, 30% Glycerol and 0.5% BSA, along with cryo-protective agents, Hepes, and long-term preservatives (0.02% Sodium Azide). |
| Purification: |
Affinity Purified |
| Concentration: |
0.5 µg/µl |
| Dilution Range: |
WB: 1:500ELISA: 1:20, 000IP: 1:200IHC: 1:100ICC: 1:100IF: 1:100 |
| Storage Instruction: |
Store at-20°C for long term storage. Avoid freeze-thaw cycles. |
| Gene Symbol: |
Abcc1 |
| Gene ID: |
24565 |
| Uniprot ID: |
MRP1_RAT |
| Immunogen: |
Synthetic peptide corresponding to unique amino acid sequences on rat multidrug resistance-associated protein 1. |
| Tissue Specificity | Skeletal muscle, brain, heart, spleen, lung and kidney. |
| Post Translational Modifications | Glycosylated. |
| Function | Mediates export of organic anions and drugs from the cytoplasm. Mediates ATP-dependent transport of glutathione and glutathione conjugates, leukotriene C4, estradiol-17-beta-o-glucuronide, methotrexate, antiviral drugs and other xenobiotics. Confers resistance to anticancer drugs by decreasing accumulation of drug in cells, and by mediating ATP- and GSH-dependent drug export. Hydrolyzes ATP with low efficiency. Catalyzes the export of sphingosine 1-phosphate from mast cells independently of their degranulation. Participates in inflammatory response by allowing export of leukotriene C4 from leukotriene C4-synthezing cells. |
| Protein Name | Multidrug Resistance-Associated Protein 1Atp-Binding Cassette Sub-Family C Member 1Glutathione-S-Conjugate-Translocating Atpase Abcc1Leukotriene C(4 TransporterLtc4 Transporter |
| Database Links | Reactome: R-RNO-1660661Reactome: -RNO-189483Reactome: -RNO-2142691Reactome: -RNO-382556Reactome: -RNO-9707564Reactome: -RNO-9753281Reactome: -RNO-9758890 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Multidrug Resistance-Associated Protein 1 antibodyAnti-Atp-Binding Cassette Sub-Family C Member 1 antibodyAnti-Glutathione-S-Conjugate-Translocating Atpase Abcc1 antibodyAnti-Leukotriene C(4 Transporter antibodyAnti-Ltc4 Transporter antibodyAnti-Abcc1 antibodyAnti-Mrp1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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